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Pub. No.:    WO/2009/123768    International Application No.:    PCT/US2009/002164
Publication Date: 08.10.2009 International Filing Date: 06.04.2009
A61K 9/16 (2006.01)
Applicants: RUTGERS UNIVERSITY [US/US]; 377 Hoes Lane Piscataway, NJ 08855-1179 (US) (For All Designated States Except US).
SINKO, Patrick, J. [US/US]; (US) (For US Only).
STEIN, Stanley [US/US]; (US) (For US Only).
KUTSCHER, Hilliard [US/US]; (US) (For US Only).
DESHMUKH, Manjeet [IN/US]; (US) (For US Only).
MENJOGE, Anupa [IN/US]; (US) (For US Only).
SINGH, Yashveer [IN/US]; (US) (For US Only)
Inventors: SINKO, Patrick, J.; (US).
STEIN, Stanley; (US).
KUTSCHER, Hilliard; (US).
DESHMUKH, Manjeet; (US).
MENJOGE, Anupa; (US).
SINGH, Yashveer; (US)
Agent: DAVIDSON, DAVIDSON & KAPPEL, LLC; 485 Seventh Avenue, 14th Floor New York, NY 10018 (US)
Priority Data:
61/042,577 04.04.2008 US
Abstract: front page image
(EN)Novel classes of multi-arm polyalkylene oxide-based materials including PEG nanocarriers, nanogel particles, and aggregated nanogel particles are disclosed. These classes of compositions may be associated with therapeutic agents and targeting moieties, or visibility enhancing agents, and may have a modified surface structure. In some embodiments the PEG-based materials can be made to provide relatively high drug loads with improved solubility and targeted delivery.
(FR)L'invention concerne de nouvelles classes de matières à base de poly(oxyde d'alkylène) à plusieurs bras comprenant des nanosupports de PEG, des particules de nanogel et des particules de nanogel agrégées. Ces classes de compositions peuvent être associées avec des agents thérapeutiques et des fractions de ciblage, ou des agents augmentant la visibilité, et peuvent avoir une structure de surface modifiée. Dans certains modes de réalisation, les matières à base PEG peuvent être réalisées pour fournir des charges de médicament relativement élevées avec une solubilité améliorée et une administration ciblée améliorée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)