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1. (WO2009123487) COMPOUNDS FOR TREATING PAIN
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2009/123487 International Application No.: PCT/PT2009/000019
Publication Date: 08.10.2009 International Filing Date: 01.04.2009
Chapter 2 Demand Filed: 01.02.2010
IPC:
C07K 5/06 (2006.01) ,A61K 31/16 (2006.01) ,A61P 25/04 (2006.01) ,C07C 279/12 (2006.01)
Applicants: RIBEIRO, Marta Maria Batista[PT/PT]; PT (UsOnly)
CASTANHO, Miguel Augusto Rico Botas[PT/PT]; PT (UsOnly)
ROCA, Christophe François Aimé[FR/PT]; PT (UsOnly)
MOREIRA DE OLIVEIRA VIEIRA, Helena Margarida[PT/PT]; PT (UsOnly)
BERNARDO DE SOUSA, José Manuel[PT/PT]; PT (UsOnly)
CEREJO, Marta Isabel Heitor[PT/PT]; PT (UsOnly)
MENDES DA SILVA CALADO, Patrícia, Ramalhete[PT/PT]; PT (UsOnly)
CHATTERJEE, Sukalyan[IN/PT]; PT (UsOnly)
RODRIGUEZ, Eduard Bardají[ES/ES]; ES (UsOnly)
COROMINAS, Montserrat Heras[ES/ES]; ES (UsOnly)
TAVARES, Isaura Ferreira[PT/PT]; PT (UsOnly)
PINTO, Marta Sofia Carvalho Teixeira[PT/PT]; PT (UsOnly)
CORREIA, Ana Dulce Ascensão[PT/PT]; PT (UsOnly)
SIMÕES DE MEL, Manuel Nuno de Sousa[PT/PT]; PT (UsOnly)
BIOALVO - SERVIÇOS, INVESTIGAÇÃO E DESENVOLVIMENTO EM BIOTECNOLOGIA S.A.[PT/PT]; Edifício ICAT - Campus da FCUL, Campo Grande 1749-016 Lisboa, PT (AllExceptUS)
Inventors: RIBEIRO, Marta Maria Batista; PT
CASTANHO, Miguel Augusto Rico Botas; PT
ROCA, Christophe François Aimé; PT
MOREIRA DE OLIVEIRA VIEIRA, Helena Margarida; PT
BERNARDO DE SOUSA, José Manuel; PT
CEREJO, Marta Isabel Heitor; PT
MENDES DA SILVA CALADO, Patrícia, Ramalhete; PT
CHATTERJEE, Sukalyan; PT
RODRIGUEZ, Eduard Bardají; ES
COROMINAS, Montserrat Heras; ES
TAVARES, Isaura Ferreira; PT
PINTO, Marta Sofia Carvalho Teixeira; PT
CORREIA, Ana Dulce Ascensão; PT
SIMÕES DE MEL, Manuel Nuno de Sousa; PT
Agent: FERREIRA MAGNO, Fernando António; Rua das Flores 74 - 4º andar P-1200-195 Lisboa, PT
CORNISH, Kristina Victoria Joy; Kilburn & Strode LLP 20 Red Lion Street London WC1R 4PJ, GB
Priority Data:
0805912.301.04.2008GB
Title (EN) COMPOUNDS FOR TREATING PAIN
(FR) COMPOSÉS POUR TRAITER LA DOULEUR
Abstract: front page image
(EN) The present invention relates to a compound of formula I (I) wherein X is hydrogen, R1, RIC(O), R1C02, or a C0X2 inhibitor, wherein R1 is C1-20 alkyl, aryl, arylalkyl, alkyloxy or arylalkyloxy; wherein Y is 0R2, NHR3 N(R3)2, or a COX inhibitor; wherein R2 is hydrogen or C1-20 alkyl and each R3 is independently hydrogen or a C1-4 alkyl; wherein T is 0R4, NHR5 N(R5)2, or a COX inhibitor; wherein R4 is hydrogen or C1-20 alkyl and each R5 is independently hydrogen or a C1-4 alkyl; wherein Z is hydrogen, R6, R6C(0), R6CO2, or a C0X2 inhibitor; wherein R6 is C1-20 alkyl, aryl, arylalkyl, alkyloxy or arylalkyloxy; with the proviso wherein when X and Z are hydrogen and T is OH, Y is not OH; for use in the prevention and/or treatment of pain wherein said compound is provided for systemic administration.
(FR) La présente invention concerne un composé de formule (I), dans laquelle X est hydrogène, R1, R1C(O), R1CO2 ou un inhibiteur de COX2, R1 est alkyle C1-20, aryle, arylalkyle, alkyloxy ou arylalkyloxy, Y est OR2, NHR3 N(R3)2 ou un inhibiteur de COX, R2 est hydrogène ou alkyle C1-20 et chaque R3 est indépendamment hydrogène ou alkyle C1-4, T est OR4, NHR5 N(R5)2 ou un inhibiteur de COX, R4 est hydrogène ou alkyle C1-20 et chaque R5 est indépendamment hydrogène ou alkyle C1-4, Z est hydrogène, R6, R6C(O), R6CO2 ou un inhibiteur de COX2, et R6 est alkyle C1-20, aryle, arylalkyle, alkyloxy ou arylalkyloxy, à condition que, lorsque X et Z sont hydrogène et T est OH, Y ne soit pas OH. Ledit composé trouve une utilisation dans la prévention et/ou le traitement de la douleur et s'administre par voie systémique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)