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1. (WO2009123099) AQUEOUS LIQUID CONTAINING GATIFLOXACIN

Pub. No.:    WO/2009/123099    International Application No.:    PCT/JP2009/056474
Publication Date: Oct 8, 2009 International Filing Date: Mar 30, 2009
IPC: A61K 31/496
A61P 27/02
A61P 31/04
Applicants: KYORIN PHARMACEUTICAL CO., LTD.
杏林製薬株式会社
SENJU PHARMACEUTICAL CO., LTD.
千寿製薬株式会社
Inventors: SAWA, Shirou
澤 嗣郎
Title: AQUEOUS LIQUID CONTAINING GATIFLOXACIN
Abstract:
Disclosed is an aqueous liquid which comprises gatifloxacin, a pharmacologically acceptable salt thereof or a hydrate of gatifloxacin or the pharmacologically acceptable salt, phosphoric acid or a salt thereof, and xanthan gum, and which has a pH value of not less than 5.5 and less than 7. The aqueous liquid exhibits improved intraocular penetration of gatifloxacin. When at least one member selected from nicotinic acid amide, caffeine, methylglucamine, methyl paraoxybenzoate and salts thereof is added to the aqueous liquid, the production of precipitates in the aqueous liquid during the storage of the aqueous liquid at a low temperature or freezing/thawing of the aqueous liquid can be prevented.