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1. (WO2009122639) ABC TRANSPORTER PROTEIN EXPRESSION INHIBITOR
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2009/122639 International Application No.: PCT/JP2009/000320
Publication Date: 08.10.2009 International Filing Date: 28.01.2009
IPC:
A61K 45/00 (2006.01) ,A61K 48/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 43/00 (2006.01)
Applicants: SUGIMOTO, Yoshikazu[JP/JP]; JP
Inventors: SUGIMOTO, Yoshikazu; JP
Agent: THE PATENT CORPORATE BODY ARUGA PATENT OFFICE; Kyodo Bldg., 3-6, Nihonbashiningyocho 1-chome, Chuo-ku Tokyo 1030013, JP
Priority Data:
2008-09072931.03.2008JP
Title (EN) ABC TRANSPORTER PROTEIN EXPRESSION INHIBITOR
(FR) INHIBITEUR DE L'EXPRESSION DE PROTÉINE DE TRANSPORTEUR ABC
(JA) ABCトランスポーター蛋白質発現抑制剤
Abstract:
(EN) Disclosed is a novel substance having an excellent inhibitory activity on the expression of ABC transporter protein and improved safety. Specifically disclosed is an ABC transporter protein expression inhibitor comprising, as an active ingredient, a substance capable of inhibiting the expression of at least one gene selected from the group consisting of ARHGAP17, CTDSP2, DUSP1, IMPA2, RHOBTB3, SGK, UBE2H, INPP5F, MAP2K6, PPM1E, PRKAG2, PRKCD, PTPN21, UBE2B, UBTF and ZNF259.
(FR) L'invention porte sur une nouvelle substance ayant une excellente activité inhibitrice sur l'expression d'une protéine de transporteur ABC et une sécurité améliorée. De façon spécifique, l'invention porte spécifiquement sur un inhibiteur de l'expression de protéine de transporteur ABC comprenant, en tant qu'ingrédient actif, une substance capable d'inhiber l'expression d'au moins un gène choisi dans le groupe constitué par ARHGAP17, CTDSP2, DUSP1, IMPA2, RHOBTB3, SGK, UBE2H, INPP5F, MAP2K6, PPM1E, PRKAG2, PRKCD, PTPN21, UBE2B, UBTF et ZNF259.
(JA)  優れたABCトランスポーター蛋白質発現抑制作用を有し且つ安全性の改善された新規な薬剤を提供する。 ARHGAP17、CTDSP2、DUSP1、IMPA2、RHOBTB3、SGK、UBE2H、INPP5F、MAP2K6、PPM1E、PRKAG2、PRKCD、PTPN21、UBE2B、UBTF及びZNF259からなる群から選ばれる1以上の遺伝子の発現を抑制する物質を有効成分とするABCトランスポーター蛋白質発現抑制剤。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)