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1. (WO2009121989) METHOD FOR OBTAINING POLYSUBSTITUTED PYRROLIDINES WITH HEPATITIS C INHIBITING ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/121989    International Application No.:    PCT/ES2009/000179
Publication Date: 08.10.2009 International Filing Date: 01.04.2009
IPC:
C07F 9/6571 (2006.01), C07F 1/10 (2006.01), C07D 207/22 (2006.01)
Applicants: UNIVERSIDAD DE ALICANTE [ES/ES]; Ctra. San Vicente del Raspeig, s/n San Vicente del Raspeig E-03690 Alicante (ES) (For All Designated States Except US).
NÁJERA DOMINGO, Carmen [ES/ES]; (ES) (For US Only).
SANSANO GIL, José Miguel [ES/ES]; (ES) (For US Only).
RETAMOSA HERNÁNDEZ, Maria de Gracia [ES/ES]; (ES) (For US Only)
Inventors: NÁJERA DOMINGO, Carmen; (ES).
SANSANO GIL, José Miguel; (ES).
RETAMOSA HERNÁNDEZ, Maria de Gracia; (ES)
Priority Data:
P200800908 02.04.2008 ES
Title (EN) METHOD FOR OBTAINING POLYSUBSTITUTED PYRROLIDINES WITH HEPATITIS C INHIBITING ACTIVITY
(ES) PROCEDIMIENTO PARA LA OBTENCIÓN DE PIRROLIDINAS POLISUSTITUIDAS INHIBIDORAS DEL VIRUS DE LA HEPATITIS C
(FR) PROCÉDÉ PERMETTANT D'OBTENIR DES PYRROLIDINES POLYSUBSTITUÉES INHIBITRICES DU VIRUS DE L'HÉPATITE C
Abstract: front page image
(EN)The invention relates to a highly enantioselective method catalysed by small quantities of a chiral complex of cationic silver, which can be used to generate polysubstituted pyrrolidines which give rise to derivatives of substituted prolines following a three-step synthetic sequence. The invention also relates to a broad sampling of chiral complexes of cationic silver and to the use of different substituents in one of the components of the key step of the total synthesis.
(ES)La presente invención se refiere a un proceso altamente enantioselectivo catalizado por pequeñas cantidades de un complejo quiral de plata catiónica que permite generar pirrolidinas polisustituidas, las cuales dan lugar a derivados de prolinas sustituidas tras una secuencia sintética de tres pasos. La invención también se refiere a un amplio muestreo de complejos quirales de plata catiónica y a la utilización de distintos sustituyentes en uno de los componentes del paso clave de esta síntesis total.
(FR)La présente invention concerne un procédé hautement enantiosélectif catalysé par des petites quantités d'un complexe chiral d'argent cationique permettant de produire des pyrrolidines polysubstituées, lesquelles permettent d'obtenir des dérivés de prolines substituées par l'intermédiaire d'une séquence synthétique en trois étapes. La présente invention concerne également un large échantillonnage de complexes chiraux d'argent cationique ainsi que l'utilisation de différents substituants dans l'un des composants de l'étape principale de ladite synthèse totale.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)