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Machine translation
1. (WO2009121958) DNER-MEDIATED CELL PURIFICATION OF PANCREATIC ENDOCRINE PRE-PROGENITOR CELLS AND THEIR PROGENY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/121958    International Application No.:    PCT/EP2009/054015
Publication Date: 08.10.2009 International Filing Date: 03.04.2009
IPC:
G01N 33/50 (2006.01), G01N 33/569 (2006.01)
Applicants: NOVO NORDISK A/S [DK/DK]; Novo Allé DK-2880 Bagsværd (DK) (For All Designated States Except US).
HALD, Jacob [DK/DK]; (DK) (For US Only).
MADSEN, Ole Dragsbæk [DK/DK]; (DK) (For US Only).
GRADWOHL, Gérard [FR/FR]; (FR) (For US Only).
MELLITZER, Georg [AT/FR]; (FR) (For US Only)
Inventors: HALD, Jacob; (DK).
MADSEN, Ole Dragsbæk; (DK).
GRADWOHL, Gérard; (FR).
MELLITZER, Georg; (FR)
Priority Data:
08103360.7 03.04.2008 EP
Title (EN) DNER-MEDIATED CELL PURIFICATION OF PANCREATIC ENDOCRINE PRE-PROGENITOR CELLS AND THEIR PROGENY
(FR) PURIFICATION DE CELLULES MÉDIÉE PAR DNER DE CELLULES PRÉ-PROGÉNITRICES ENDOCRINES PANCRÉATIQUES ET DE LEURS DESCENDANTS
Abstract: front page image
(EN)The invention relates to a method of identifying and obtaining a culture cells comprising cells selected from the group consisting of endocrine pre-progenitor cells, endocrine progenitor cells, early endocrine cells, and/or fully differentiated endocrine cells. Also contemplated is a method of expanding the number of such cells as well as sorting such cells. In some aspects the invention further relates to a selective cell surface marker, DNER, that permits the selection of a unique subset of cells with endocrine pre-progenitor, endocrine progenitor, early endocrine, and/or fully differentiated endocrine phenotype. In some aspects the selective cell surface marker is selected from the group consisting of DNER, DISP2, SEZ6L2, LRP1 1 and SLC30A8. Furthermore, the invention relates to isolated cells selected from such cells and compositions thereof.
(FR)L'invention concerne un procédé d'identification et d'obtention de cellules en culture comprenant des cellules choisies dans l'ensemble consistant en cellules pré-progénitrices, cellules progénitrices endocrines, cellules endocrines précoces, et/ou cellules endocrines complètement différenciées. Elle concerne également un procédé de multiplication du nombre de ces cellules ainsi que de tri de ces cellules. Dans certains aspects, l'invention concerne en outre un marqueur de surface cellulaire sélectif, DNER, qui permet la sélection d'un sous-ensemble unique de cellules avec un phénotype pré-progéniteur endocrine, progéniteur endocrine, endocrine précoce, et/ou endocrine complètement différencié. Dans certains aspects, le marqueur de surface cellulaire sélectif est choisi dans l'ensemble consistant en DNER, DISP2, SEZ6L2, LRP1 1 et SLC30A8. En outre, l'invention concerne des cellules isolées sélectionnées parmi ces cellules, et des compositions de celles-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)