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1. (WO2009121872) TETRAHYDROISOQUINOLINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY

Pub. No.:    WO/2009/121872    International Application No.:    PCT/EP2009/053800
Publication Date: Oct 8, 2009 International Filing Date: Mar 31, 2009
IPC: C07D 217/18
C07D 401/06
C07D 401/12
C07D 409/14
C07D 413/12
C07D 417/12
C07D 498/04
C07D 513/04
A61K 31/472
A61P 25/28
Applicants: ABBOTT GMBH & CO. KG
ABBOTT LABORATORIES
AMBERG, Wilhelm
OCHSE, Michael
LANGE, Udo
BRAJE, Wilfried
BEHL, Berthold
HORNBERGER, Wilfried
MEZLER, Mario
HUTCHINS, Charles W.
Inventors: AMBERG, Wilhelm
OCHSE, Michael
LANGE, Udo
BRAJE, Wilfried
BEHL, Berthold
HORNBERGER, Wilfried
MEZLER, Mario
HUTCHINS, Charles W.
Title: TETRAHYDROISOQUINOLINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY
Abstract:
The present invention relates to tetrahydroisoquinoline of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such tetrahydroisoquinolines, and the use of such tetrahydroisoquinolines for therapeutic purposes. The tetrahydroisoquinolines are GIyT1 inhibitors.