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Machine translation
1. (WO2009121710) PROCESS FOR PREPARING NEBIVOLOL
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/121710    International Application No.:    PCT/EP2009/053051
Publication Date: 08.10.2009 International Filing Date: 16.03.2009
IPC:
C07D 311/58 (2006.01), C07D 407/04 (2006.01)
Applicants: ZACH SYSTEM S.P.A. [IT/IT]; Via Lillo del Duca, 10 I-20091 Bresso (Milano) (IT) (For All Designated States Except US).
VOLPICELLI, Raffaella [IT/IT]; (IT) (For US Only).
MARAGNI, Paolo [IT/IT]; (IT) (For US Only).
MASSACCESI, Franco [IT/IT]; (IT) (For US Only).
MUNARI, Ilaria [IT/IT]; (IT) (For US Only).
COTARCA, Livius [IT/IT]; (IT) (For US Only).
FOLETTO, Johnny [IT/IT]; (IT) (For US Only)
Inventors: VOLPICELLI, Raffaella; (IT).
MARAGNI, Paolo; (IT).
MASSACCESI, Franco; (IT).
MUNARI, Ilaria; (IT).
COTARCA, Livius; (IT).
FOLETTO, Johnny; (IT)
Common
Representative:
ZACH SYSTEM S.P.A.; Patent Office Via Lillo del Duca, 10 I-20091 Bresso (Milano) (IT)
Priority Data:
MI2008A000547 31.03.2008 IT
Title (EN) PROCESS FOR PREPARING NEBIVOLOL
(FR) PROCÉDÉ DE PRÉPARATION DU NEBIVOLOL
Abstract: front page image
(EN)The present invention relates to a process for reducing a compound of formula (I) wherein X is halogen, a hydroxy group, an alkylsulfoniloxy group or an arylsulfonyloxy group; to give a compound of formula (II) as a diastereoisomerically pure compound of RS/SR configuration characterized in that said reduction is carried out by the use of (+)-B- chlorodiisopinocampheylborane or (-)-B- chlorodiisopinocampheylborane. The compounds of formula (II) are useful as intermediates for the preparation of Nebivolol.
(FR)La présente invention porte sur un procédé de préparation du Nebivolol et, plus particulièrement, sur un procédé permettant la réduction stéréosélective d'une alpha-halocétone de formule (I) : intermédiaire utile pour la préparation du Nebivolol.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)