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1. (WO2009121483) HIGHLY BRIDGED PEPTIDES FROM ACTINOMADURA NAMIBIENSIS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2009/121483 International Application No.: PCT/EP2009/001982
Publication Date: 08.10.2009 International Filing Date: 18.03.2009
Chapter 2 Demand Filed: 20.01.2010
IPC:
C07K 14/36 (2006.01) ,C07K 7/08 (2006.01) ,A61K 38/10 (2006.01) ,A61P 31/04 (2006.01) ,A61P 31/12 (2006.01) ,C12P 21/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
36
from Actinomyces; from Streptomyces (G)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
08
having 12 to 20 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
10
Peptides having 12 to 20 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
02
having a known sequence of two or more amino acids, e.g. glutathione
Applicants:
SANOFI-AVENTIS [FR/FR]; 174, Avenue de France F-75013 Paris, FR (AllExceptUS)
BROENSTRUP, Mark [DE/DE]; DE (UsOnly)
GUEHRING, Hans [DE/DE]; DE (UsOnly)
HOFFMANN, Holger [DE/DE]; DE (UsOnly)
WINK, Joachim [DE/DE]; DE (UsOnly)
SUESSMUTH, Roderich [DE/DE]; DE (UsOnly)
SCHMIEDERER, Timo [DE/DE]; DE (UsOnly)
Inventors:
BROENSTRUP, Mark; DE
GUEHRING, Hans; DE
HOFFMANN, Holger; DE
WINK, Joachim; DE
SUESSMUTH, Roderich; DE
SCHMIEDERER, Timo; DE
Agent:
SIEBER, Frank; c/o Sanofi-Aventis Deutschland GmbH Patents Germany Industriepark Höchst, Gebäude K 801 65926 Frankfurt am Main, DE
Priority Data:
08290324.602.04.2008EP
Title (EN) HIGHLY BRIDGED PEPTIDES FROM ACTINOMADURA NAMIBIENSIS
(FR) PEPTIDES HAUTEMENT PONTÉS PROVENANT D'ACTINOMADURA NAMIBIENSIS
Abstract:
(EN) The invention refers to so-called Labyrinthopeptin derivatives of the formula (I) wherein {A}, {B}, {C}, R1-R6, m and n are as defined herein, obtainable from microorganism strain Actinomadura namibiensis (DSM 6313), its use for the treatment of bacterial infections, viral infections and/or pain, a pharmaceutical composition comprising it, prepro-Labyrinthopeptin, pro-Labyrinthopeptin, and DNA coding for prepro-Labyrinthopeptin and pro-Labyrinthopeptin.
(FR) L'invention porte sur des dérivés dits de Labyrinthopeptine représentés par la formule (I) dans laquelle {A}, {B}, {C}, R1-R6, m et n sont tels que définis présentement, pouvant être obtenus à partir de la souche de micro-organisme Actinomadura namibiensis (DSM 6313), sur leur utilisation pour le traitement d'infections bactériennes, d'infections virales et/ou de la douleur, sur une composition pharmaceutique les comprenant, sur une prépro-Labyrinthopeptine, sur une pro-Labyrinthopeptine et sur un ADN codant pour la prépro-Labyrinthopeptine et la pro-Labyrinthopeptine.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AR071125IL208239SG164966EP2271665JP2011516048MXMX/a/2010/010115
US20110144001RU2010144778CN102046652CA2720173RU0002498995KR1020110014563
AU2009231118MYPI 2010004183TH106972IN6237/CHENP/2010