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Machine translation
1. (WO2009120922) COMPOSITIONS AND METHODS FOR INHIBITING PDGFRBETA AND VEGF-A
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/120922    International Application No.:    PCT/US2009/038495
Publication Date: 01.10.2009 International Filing Date: 27.03.2009
IPC:
A61K 39/395 (2006.01), A61P 35/00 (2006.01), C07K 16/22 (2006.01), C07K 16/28 (2006.01)
Applicants: ZYMOGENETICS, INC. [US/US]; 1201 Eastlake Avenue East Seattle, WA 98102 (US) (For All Designated States Except US).
SIVAKUMAR, Pallavur, V. [IN/US]; (US) (For US Only).
GILBERTSON, Debra, G. [US/US]; (US) (For US Only).
SNAVELY, Marshall, D. [US/US]; (US) (For US Only).
MABRY, George, R. [US/US]; (US) (For US Only).
YI, Eugene, C. [US/US]; (US) (For US Only).
YAO, Yue [US/US]; (US) (For US Only).
PRESNELL, Scott, R. [US/US]; (US) (For US Only)
Inventors: SIVAKUMAR, Pallavur, V.; (US).
GILBERTSON, Debra, G.; (US).
SNAVELY, Marshall, D.; (US).
MABRY, George, R.; (US).
YI, Eugene, C.; (US).
YAO, Yue; (US).
PRESNELL, Scott, R.; (US)
Agent: SHERBINA, Nicholas, V.; (US)
Priority Data:
61/040,068 27.03.2008 US
61/144,547 14.01.2009 US
Title (EN) COMPOSITIONS AND METHODS FOR INHIBITING PDGFRBETA AND VEGF-A
(FR) COMPOSITIONS ET PROCÉDÉS POUR INHIBER PDGFR-BÊTA ET VEGF-A
Abstract: front page image
(EN)Disclosed are antagonists of PDGF receptor β (PDGFRβ) and VEGF-A, including neutralizing anti-PDGFRβ and anti-VEGF-A antibodies, as well as related compositions and methods. Anti-PDGFRβ and anti-VEGF-A antibodies disclosed herein include bispecific antibodies capable of binding and neutralizing both PDGFRβ and VEGF-A. Also disclosed are methods of treating an neovascular disorder, such as cancer or an neovascular ocular disorder, using a PDGFRβ and/or VEGF-A antagonist.
(FR)La présente invention concerne des antagonistes de récepteur β de PDGF (PDGFRβ) et VEGF-A, comprenant la neutralisation d’anticorps anti-PDGFRβ et anti-VEGF-A, ainsi que des compositions et procédés associés. Les anticorps anti-PDGFRβ et anti-VEGF-A présentement décrits comprennent des anticorps bispécifiques capables de se lier à et neutraliser PDGFRβ et VEGF-A. L’invention concerne également des procédés de traitement d’un trouble néovasculaire, tel que le cancer ou un trouble oculaire néovasculaire, utilisant un antagoniste de PDGFRβ et/ou VEGF-A.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)