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1. (WO2009120803) WATER SOLUBLE SMALL MOLECULE INHIBITORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/120803    International Application No.:    PCT/US2009/038292
Publication Date: 01.10.2009 International Filing Date: 25.03.2009
IPC:
A61P 11/00 (2006.01), A61K 31/426 (2006.01), A61K 31/427 (2006.01), A61K 31/4427 (2006.01), A61P 13/12 (2006.01), A61P 33/00 (2006.01), C07D 277/36 (2006.01), C07D 417/06 (2006.01), C07D 417/10 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 12th Floor 1111 Franklin Street Oakland, CA 94607 (US) (For All Designated States Except US).
VERKMAN, Alan, S. [US/US]; (US) (For US Only).
SONAWANE, Nitin, D. [IN/US]; (US) (For US Only)
Inventors: VERKMAN, Alan, S.; (US).
SONAWANE, Nitin, D.; (US)
Agent: ROSOK, Mae, Joanne; Seed Intellectual Property Law Group PLLC Suite 5400 701 Fifth Avenue Seattle, WA 98104-7064 (US)
Priority Data:
61/039,379 25.03.2008 US
61/084,228 28.07.2008 US
Title (EN) WATER SOLUBLE SMALL MOLECULE INHIBITORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
(FR) INHIBITEURS À PETITE MOLÉCULE SOLUBLE DANS L'EAU DU RÉGULATEUR DE CONDUCTANCE TRANSMEMBRANAIRE DE FIBROSE KYSTIQUE
Abstract: front page image
(EN)Provided herein are highly water soluble, thiazolidinone derivative compounds and glycine hydrazide derivative compounds that inhibit the ion transport activity of the cystic fibrosis transmembrane conductance regulator (CFTR). The compounds, and compositions comprising the compounds, described herein are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased CFTR activity, for example, secretory diarrhea. The compounds may also be used for inhibiting expansion or preventing formation of cysts in persons who have polycystic kidney disease.
(FR)La présente invention concerne des composés dérivés de thiazolidinone hautement soluble dans l'eau et des composés dérivés de glycine hydrazine qui inhibent l'activité de transport ionique du régulateur de conductance transmembranaire de fibrose kystique (CFTR). Les composés et compositions comprenant les composés décrits ici sont utiles pour traiter des maladies, troubles et séquelles de maladies, troubles et des affections qui sont associés à une activité de CFTR accrue de façon aberrante, par exemple, une diarrhée sécrétoire. Les composés peuvent également être utilisés pour inhiber une propagation ou empêcher une formation de kystes chez les personnes ayant une maladie rénale polykystique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)