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1. (WO2009120611) ALDEHYDE TAGS, USES THEREOF IN SITE-SPECIFIC PROTEIN MODIFICATION

Pub. No.:    WO/2009/120611    International Application No.:    PCT/US2009/037893
Publication Date: Oct 1, 2009 International Filing Date: Mar 20, 2009
IPC: C12P 21/04
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
RUSH, Jason, S.
BERTOZZI, Carolyn
Inventors: RUSH, Jason, S.
BERTOZZI, Carolyn
Title: ALDEHYDE TAGS, USES THEREOF IN SITE-SPECIFIC PROTEIN MODIFICATION
Abstract:
The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide.