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1. (WO2009120140) NOVEL 5,7-DISUBSTITUTED [1,3]THIAZOLO[4,5-D]PYRIMIDIN-2(3H)-ONE DERIVATIVES 258
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/120140    International Application No.:    PCT/SE2009/050310
Publication Date: 01.10.2009 International Filing Date: 25.03.2009
IPC:
C07D 513/04 (2006.01), A61K 31/519 (2006.01), A61P 11/06 (2006.01), A61P 25/00 (2006.01), A61P 9/10 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje (SE) (For All Designated States Except US).
DAHLSTRÖM, Mikael [FI/SE]; (SE) (For US Only).
NORDVALL, Gunnar [SE/SE]; (SE) (For US Only).
REIN, Tobias [SE/SE]; (SE) (For US Only).
STARKE, Ingemar [SE/SE]; (SE) (For US Only)
Inventors: DAHLSTRÖM, Mikael; (SE).
NORDVALL, Gunnar; (SE).
REIN, Tobias; (SE).
STARKE, Ingemar; (SE)
Agent: ASTRAZENECA AB; AstraZeneca Intellectual Property S-151 85 Södertälje (SE)
Priority Data:
61/039,463 26.03.2008 US
Title (EN) NOVEL 5,7-DISUBSTITUTED [1,3]THIAZOLO[4,5-D]PYRIMIDIN-2(3H)-ONE DERIVATIVES 258
(FR) NOUVEAUX DÉRIVÉS 258 DE [1,3]THIAZOLO[4,5-D]PYRIMIDIN-2(3H)-ONE 5,7-DISUBSTITUÉS
Abstract: front page image
(EN)There are disclosed novel 5,7-disubstituted [1,3]thiazolo[4,5-d]pyrimidin-2(3H)-one derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification, and pharmaceutically acceptable salts thereof, together with processes for their preparation, pharmaceutical compositions comprising them and their use in therapy. The compounds of formula (I) are CX3CR1 receptor antagonists and are thereby particularly useful in the treatment or prophylaxis of neurodegenerative disorders, demyelinating disease, cardio- and cerebrovascular atherosclerotic disorders, peripheral artery disease, rheumatoid arthritis, pulmonary diseases such as COPD, asthma or pain.
(FR)L'invention porte sur de nouveaux dérivés de [1,3]thiazolo[4,5-d]pyrimidin-2(3H)-one 5,7-disubstitués représentés par la formule (I) dans laquelle R1, R2, R3, R4, R5, R6 et R7 sont tels que définis dans la description, et sur leurs sels pharmaceutiquement acceptables, conjointement avec des procédés pour leur préparation, des compositions pharmaceutiques les comprenant et leur utilisation en thérapie. Les composés de formule (I) sont des antagonistes du récepteur CX3CR1 et sont de ce fait particulièrement utiles dans le traitement ou la prophylaxie de troubles neurodégénératifs, d'une maladie démyélinisante, de troubles athérosclérotiques cardio- et cérébrovasculaires, d'une maladie artérielle périphérique, de la polyarthrite rhumatoïde, de maladies pulmonaires telles que la maladie pulmonaire obstructive chronique, de l'asthme ou de la douleur.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)