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1. (WO2009120082) MEANS AND METHODS FOR INFLUENCING ELECTRICAL ACTIVITY OF CELLS

Pub. No.:    WO/2009/120082    International Application No.:    PCT/NL2009/050153
Publication Date: Oct 1, 2009 International Filing Date: Mar 27, 2009
IPC: A61K 38/17
Applicants: ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
BOINK, Gerard J.J.
TAN, Hanno L.
Inventors: BOINK, Gerard J.J.
TAN, Hanno L.
Title: MEANS AND METHODS FOR INFLUENCING ELECTRICAL ACTIVITY OF CELLS
Abstract:
The invention provides means and methods for providing a cell with a spontaneous electrical activity and means and methods for increasing the depolarization rate of a cell having a spontaneous electrical activity. Means and methods are provided comprising: - providing a cell with a compound capable of providing and/or increasing a pacemaker current If, and - diminishing electrical coupling between said cell and surrounding cells and/or reducing the inward rectifier current IK1 of said cell, and or increasing the availability of lNa at depolarized potentials, preferably using overexpression of additional sodium channels.