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1. (WO2009119980) BENZOPHENONE THIAZOLE DERIVATIVES USEFUL FOR INHIBITING FORMATION OF MICROTUBULE AND METHOD FOR PRODUCING THE SAME

Pub. No.:    WO/2009/119980    International Application No.:    PCT/KR2009/001095
Publication Date: Oct 1, 2009 International Filing Date: Mar 5, 2009
IPC: C07D 417/10
C07D 213/69
C07D 249/08
C07D 285/00
C07C 49/786
A61K 31/426
A61K 31/4192
A61K 8/35
A61P 35/00
Applicants: CHONG KUN DANG PHARMACEUTICAL CORP.
주식회사 종근당
CHOI, Nam-Song
최남송
KIM, Young-Hoon
김영훈
LEE, Jae-Kwang
이재광
KANG, Hee-Ryong
강희룡
CHOI, Ho-Jin
최호진
MOON, Seung-Kee
문승기
KIM, Soo-Jin
김수진
PARK, Gyu-Tae
박규태
HAN, Byeong-Hoon
한병훈
KIM, Dal-Hyun
김달현
CHOI, Jae-Hoon
최재훈
LEE, Sung-Sook
이성숙
AHN, Soon-Kil
안순길
LEE, Kyung-Joo
이경주
BAE, Su-Yeal
배수열
Inventors: CHOI, Nam-Song
최남송
KIM, Young-Hoon
김영훈
LEE, Jae-Kwang
이재광
KANG, Hee-Ryong
강희룡
CHOI, Ho-Jin
최호진
MOON, Seung-Kee
문승기
KIM, Soo-Jin
김수진
PARK, Gyu-Tae
박규태
HAN, Byeong-Hoon
한병훈
KIM, Dal-Hyun
김달현
CHOI, Jae-Hoon
최재훈
LEE, Sung-Sook
이성숙
AHN, Soon-Kil
안순길
LEE, Kyung-Joo
이경주
BAE, Su-Yeal
배수열
Title: BENZOPHENONE THIAZOLE DERIVATIVES USEFUL FOR INHIBITING FORMATION OF MICROTUBULE AND METHOD FOR PRODUCING THE SAME
Abstract:
The present invention relates to novel benzophenone thiazole derivatives of chemical formula 1, isomers thereof, pharmaceutically acceptable salts thereof, hydrates thereof or solvates thereof, pharmaceutical compositions containing the same, use thereof as therapeutic agents and a method for producing the same. The benzophenone thiazole derivatives of the present invention have inhibitory activities against the formation of microtubules, and exterminate active proliferating cells of malignant tumors and thus can be used in treating the general growth state of a malignant tumor. R, R1 and R2 in chemical formula 1 are the same as those defined in the description of the invention.