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1. (WO2009119785) METHOD FOR PURIFYING ETHYNYLTHYMIDINE COMPOUND
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/119785    International Application No.:    PCT/JP2009/056219
Publication Date: 01.10.2009 International Filing Date: 27.03.2009
IPC:
C07D 405/04 (2006.01), A61K 31/506 (2006.01), A61P 31/18 (2006.01), A61P 37/04 (2006.01), A61P 43/00 (2006.01), C07H 19/073 (2006.01)
Applicants: HAMARI CHEMICALS, LTD. [JP/JP]; 4-29, Kunijima 1-chome, Higashiyodogawa-ku, Osaka-shi, Osaka, 5330024 (JP) (For All Designated States Except US).
MIWA, Toshio [JP/JP]; (JP) (For US Only).
SATO, Tatsunori [JP/JP]; (JP) (For US Only)
Inventors: MIWA, Toshio; (JP).
SATO, Tatsunori; (JP)
Agent: IWATANI, Ryo; KEIHAN Dojima Bldg. 3F, 1-31, Dojima 2-chome, Kita-ku, Osaka-shi, Osaka, 5300003 (JP)
Priority Data:
2008-088669 28.03.2008 JP
Title (EN) METHOD FOR PURIFYING ETHYNYLTHYMIDINE COMPOUND
(FR) PROCÉDÉ DE PURIFICATION D'UN COMPOSÉ D'ÉTHYNYLTHYMIDINE
(JA) エチニルチミジン化合物の精製方法
Abstract: front page image
(EN)Disclosed is a method for purifying 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine or a base salt thereof, which is characterized in that a crystal of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine or a base salt thereof is deposited by bringing a solution containing a base salt of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine and a base salt of a diastereomer of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine into contact with a solvent in which base salts of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine are poorly soluble. The method can efficiently and commercially advantageously purify 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine or a base salt thereof, which is useful as a pharmaceutical product.
(FR)Cette invention concerne un procédé de purification de 2',3'-didéshydro- 3'-désoxy-4'-éthynylthymidine ou d'un de ses sels de base, qui est caractérisé en ce qu'un cristal de 2',3'-didéshydro-3'-désoxy-4'-éthynyl- thymidine ou d'un de ses sels de base est déposé par mise en contact d'une solution contenant un sel de base de 2',3'-didéshydro-3'-désoxy-4'-éthynyl- thymidine et un sel de base d'un diastéréomère 2',3'-didéshydro- 3'-désoxy-4'-éthynylthymidine avec un solvant dans lequel les sels de base sont peu solubles. Le procédé permet de purifier efficacement et d'une manière commercialement avantageuse la 2',3'-didéshydro-3'-désoxy-4'-éthynyl- thymidine ou un de ses sels de base, qui sont des produits pharmaceutiques utiles.
(JA) 本発明は、下記式[I]: で示される2’,3’-ジデヒドロ-3’-デオキシ-4’-エチニルチミジンの塩基塩およびそのジアステレオマー塩基塩を含有する溶液と2’,3’-ジデヒドロ-3’-デオキシ-4’-エチニルチミジンの塩基塩が難溶性である溶媒とを接触させ、2’,3’-ジデヒドロ-3’-デオキシ-4’-エチニルチミジンまたはその塩基塩の結晶を晶析させることを特徴とする2’,3’-ジデヒドロ-3’-デオキシ-4’-エチニルチミジンまたはその塩基塩の精製方法である。本発明は医薬として有用な2’,3’-ジデヒドロ-3’-デオキシ-4’-エチニルチミジンまたはその塩基塩を効率的にかつ工業的有利に精製する方法を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)