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1. WO2009118658 - ENDOPLASMIC RETICULUM TARGETING LIPOSOMES

Publication Number WO/2009/118658
Publication Date 01.10.2009
International Application No. PCT/IB2009/005547
International Filing Date 25.03.2009
IPC
A61K 9/127 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
CPC
A61K 31/445
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
A61K 9/0019
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
A61K 9/127
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 9/1271
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
Applicants
  • UNIVERSITY OF OXFORD [GB]/[GB] (AllExceptUS)
  • POLLOCK, Stephanie [CA]/[GB] (UsOnly)
  • DWEK, Raymond, Allen [GB]/[GB] (UsOnly)
  • ZITZMANN, Nicole [DE]/[GB] (UsOnly)
Inventors
  • POLLOCK, Stephanie
  • DWEK, Raymond, Allen
  • ZITZMANN, Nicole
Priority Data
61/039,63826.03.2008US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ENDOPLASMIC RETICULUM TARGETING LIPOSOMES
(FR) LIPOSOMES CIBLANT LE RÉTICULUM ENDOPLASMIQUE
Abstract
(EN) Provided are compositions that include lipid particles, such as liposomes, that can fuse with the ER membrane of a cell. The lipid particles can also deliver a cargo, such as a therapeutic or an imaging agent, encapsulated inside the particles inside the ER lumen of the cell. The compositions can be useful for treating and/or preventing diseases or conditions caused by or associated with a virus, such as viral infections, including HIV and HCV infections.
(FR) La présente invention concerne des compositions qui comprennent des particules de lipides, telles que des liposomes, qui peuvent fusionner avec la membrane du réticulum endoplasmique (RE) d’une cellule. Les particules de lipides peuvent également délivrer une charge, telle qu’un agent thérapeutique ou d’imagerie, encapsulée à l’intérieur des particules à l’intérieur de la lumière du RE de la cellule. Les compositions peuvent être utiles pour traiter et/ou prévenir des maladies ou pathologies causées par ou associées à un virus, telles que des infections virales, comprenant les infections par le VIH ou le VHC.
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