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1. WO2009114335 - PD-1 BINDING PROTEINS

Publication Number WO/2009/114335
Publication Date 17.09.2009
International Application No. PCT/US2009/035825
International Filing Date 03.03.2009
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C12P 21/08 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21Preparation of peptides or proteins
08Monoclonal antibodies
CPC
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C07K 16/2896
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2896against molecules with a "CD"-designation, not provided for elsewhere
C07K 2317/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
24containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
C07K 2317/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
56variable (Fv) region, i.e. VH and/or VL
C07K 2317/565
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
56variable (Fv) region, i.e. VH and/or VL
565Complementarity determining region [CDR]
C07K 2317/92
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
90characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applicants
  • MERCK SHARP & DOHME CORP. [US]/[US] (AllExceptUS)
  • FINNEFROCK, Adam, C. [US]/[US] (UsOnly)
  • FU, Tong-Ming [US]/[US] (UsOnly)
  • FREED, Daniel, C. [US]/[US] (UsOnly)
  • CASIMIRO, Danilo, R. [US]/[US] (UsOnly)
  • LI, Fengsheng [US]/[US] (UsOnly)
  • TANG, Aimin [US]/[US] (UsOnly)
Inventors
  • FINNEFROCK, Adam, C.
  • FU, Tong-Ming
  • FREED, Daniel, C.
  • CASIMIRO, Danilo, R.
  • LI, Fengsheng
  • TANG, Aimin
Common Representative
  • MERCK SHARP & DOHME CORP.
Priority Data
61/069,06012.03.2008US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PD-1 BINDING PROTEINS
(FR) PROTÉINES DE LIAISON AVEC PD-1
Abstract
(EN)
The present invention features PD-1 binding proteins, a subset of which inhibits binding of PD-L1 to the PD-1 receptor. These binding proteins can be employed to modulate the immune system through the manipulation of the PD-1 signaling pathway, enhancing host immunity to treat infections and cancer.
(FR)
La présente invention porte sur des protéines de liaison avec PD-1, dont un sous-ensemble inhibe la liaison de PD-L1 avec le récepteur PD-1. Ces protéines de liaison peuvent être employées pour moduler le système immunitaire par la manipulation de la voie de signalisation PD-1, améliorant l'immunité d'hôte pour traiter des infections et le cancer.
Also published as
Latest bibliographic data on file with the International Bureau