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1. (WO2009103113) HUMANIZED ANTI-C5aR ANTIBODIES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2009/103113 International Application No.: PCT/AU2009/000184
Publication Date: 27.08.2009 International Filing Date: 19.02.2009
IPC:
C07K 16/28 (2006.01) ,A61K 39/395 (2006.01) ,C12N 15/13 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
12
Genes encoding animal proteins
13
Immunoglobulins
Applicants:
G2 INFLAMMATION PTY LTD [AU/AU]; Level 10 384 Victoria Street Darlinghurst , New South Wales 2010, AU (AllExceptUS)
WHITFELD, Peter [AU/AU]; AU (UsOnly)
ZAHRA, David [AU/AU]; AU (UsOnly)
MACKAY, Charles [AU/AU]; AU (UsOnly)
Inventors:
WHITFELD, Peter; AU
ZAHRA, David; AU
MACKAY, Charles; AU
Agent:
FB RICE & CO; Level 23 200 Queen Street Melbourne , Victoria 3000, AU
Priority Data:
61/066,53920.02.2008US
Title (EN) HUMANIZED ANTI-C5aR ANTIBODIES
(FR) ANTICORPS ANTI-C5AR HUMANISÉS
Abstract:
(EN) The present invention is directed to humanized antibodies which bind the human C5a receptor and their use as therapeutic and diagnostic agents. The present invention is further directed toward nucleic acid sequences which encode said humanized antibodies, and their expression in recombinant host cells. In particular, the present invention is directed towards humanized antibodies derived from murine antibody 7F3 which specifically binds to the human C5a receptor.
(FR) La présente invention concerne des anticorps humanisés qui se lient au récepteur C5a humain, ainsi que leur utilisation en tant qu'agents thérapeutiques et de diagnostic. La présente invention concerne également des séquences d'acides nucléiques codant lesdits anticorps humanisés et leur expression dans des cellules hôtes recombinées. La présente invention concerne, en particulier, des anticorps humanisés issus de l'anticorps murin 7F3 qui se lie de façon spécifique au récepteur C5a humain.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IL207217EP2254911JP2011515073MXMX/a/2010/009190US20110190477RU2010138612
CN101970494CA2714296JP2014193164CN104193824EP2826791KR1020100117120
BRPI0907532ES2562627AU2009217224IN5572/DELNP/2010