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1. WO2009100130 - AMPK MODULATORS

Publication Number WO/2009/100130
Publication Date 13.08.2009
International Application No. PCT/US2009/033077
International Filing Date 04.02.2009
IPC
A01N 31/04 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
31Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
04Oxygen or sulfur attached to an aliphatic side chain of a carbocyclic ring system
CPC
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07D 209/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
08with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
C07D 209/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
10with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
12Radicals substituted by oxygen atoms
Applicants
  • MERCURY THERAPEUTICS, INC. [US]/[US] (AllExceptUS)
  • BIRNBERG, Neal, C. [US]/[US] (UsOnly)
  • LIU, Hong [CN]/[US] (UsOnly)
  • WENG, Qing, Peng [US]/[US] (UsOnly)
  • SHANG, Haibo [CN]/[US] (UsOnly)
  • YIN, Pan [CN]/[US] (UsOnly)
  • RAJUR, Sharanappa, B. [US]/[US] (UsOnly)
  • KIM, Hwa-Ok [US]/[US] (UsOnly)
  • SALGAONKAR, Paresh, D. [IN]/[US] (UsOnly)
  • PEET, Norton, P. [US]/[US] (UsOnly)
Inventors
  • BIRNBERG, Neal, C.
  • LIU, Hong
  • WENG, Qing, Peng
  • SHANG, Haibo
  • YIN, Pan
  • RAJUR, Sharanappa, B.
  • KIM, Hwa-Ok
  • SALGAONKAR, Paresh, D.
  • PEET, Norton, P.
Agents
  • ELMORE, Carolyn, S.
Priority Data
61/026,00104.02.2008US
61/051,20007.05.2008US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) AMPK MODULATORS
(FR) MODULATEURS DE L'AMPK
Abstract
(EN) The present invention relates to compounds and pharmaceutically acceptable salts, esters and prodrugs of Formula (I) or (II), which are useful as AMPK modulators effective in treating diabetes, obesity and cancer in a subject.
(FR) La présente invention concerne des composés et des sels de qualité pharmaceutique, des esters et des promédicaments représentés par la Formule (I) ou (II), qui s’utilisent en tant que modulateurs de l'AMPK, et qui sont efficaces dans le traitement du diabète, de l'obésité et du cancer chez un sujet.
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