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1. WO2009098453 - AZONIA BICYCLOALKANES AS M3 MUSCARINIC ACETYLCHOLIN RECEPTOR ANTAGONISTS

Publication Number WO/2009/098453
Publication Date 13.08.2009
International Application No. PCT/GB2009/000306
International Filing Date 05.02.2009
IPC
C07D 453/02 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
453Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02containing not further condensed quinuclidine ring systems
A61K 31/439 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
439the ring forming part of a bridged ring system, e.g. quinuclidine
A61P 11/06 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
CPC
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
C07D 453/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
453Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02containing not further condensed quinuclidine ring systems
Applicants
  • ASTRAZENECA AB [SE]/[SE] (AllExceptUS)
  • ARGENTA DISCOVERY LIMITED [GB]/[GB] (AllExceptUS)
  • BULL, Richard, James [GB]/[GB] (UsOnly)
  • NADIN, Alan, John [GB]/[GB] (UsOnly)
  • RAY, Nicholas, Charles [GB]/[GB] (UsOnly)
  • SMITH, Phillip [GB]/[GB] (UsOnly)
Inventors
  • BULL, Richard, James
  • NADIN, Alan, John
  • RAY, Nicholas, Charles
  • SMITH, Phillip
Agents
  • ASTRAZENECA AB
Priority Data
0802195.806.02.2008GB
0802666.813.02.2008GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) AZONIA BICYCLOALKANES AS M3 MUSCARINIC ACETYLCHOLIN RECEPTOR ANTAGONISTS
(FR) AZONIA BICYCLOALCANES COMME ANTAGONISTES DU RÉCEPTEUR D'ACÉTYLCHOLINE MUSCARINIQUE M3
Abstract
(EN) This invention relates to M3 antagonists of formula (I): wherein R2, R4, R5, R6, W, V, A, D, X, t, u and v are as defined herein; pharmaceutical compositions containing them; methods for their preparation; and their use in the treatment of diseases where enhanced M3 receptor activation is implicated.
(FR) L'invention concerne des antagonistes M3 de formule (I): dans laquelle R2, R4, R5, R6, W, V, A, D, X, t, u et v sont tels que définis dans le descriptif; des compositions pharmaceutiques les contenant; leurs procédés de préparation; et leur utilisation dans le traitement de maladies appelant l'activation renforcée du récepteur M3.
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