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1. (WO2009098453) AZONIA BICYCLOALKANES AS M3 MUSCARINIC ACETYLCHOLIN RECEPTOR ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2009/098453 International Application No.: PCT/GB2009/000306
Publication Date: 13.08.2009 International Filing Date: 05.02.2009
IPC:
C07D 453/02 (2006.01) ,A61K 31/439 (2006.01) ,A61P 11/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
453
Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02
containing not further condensed quinuclidine ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
439
the ring forming part of a bridged ring system, e.g. quinuclidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
06
Antiasthmatics
Applicants:
BULL, Richard, James [GB/GB]; GB (UsOnly)
NADIN, Alan, John [GB/GB]; GB (UsOnly)
RAY, Nicholas, Charles [GB/GB]; GB (UsOnly)
SMITH, Phillip [GB/GB]; GB (UsOnly)
ASTRAZENECA AB [SE/SE]; 151 85 Sodertalje, SE (AllExceptUS)
ARGENTA DISCOVERY LIMITED [GB/GB]; 8/9 Spire Green Centre Flex Meadow Harlow CM19 5TR, GB (AllExceptUS)
Inventors:
BULL, Richard, James; GB
NADIN, Alan, John; GB
RAY, Nicholas, Charles; GB
SMITH, Phillip; GB
Agent:
ASTRAZENECA AB; Attn: Kevin Stansfield AstraZeneca Intellectual Property SE-151 85 Södertälje, SE
Priority Data:
0802195.806.02.2008GB
0802666.813.02.2008GB
Title (EN) AZONIA BICYCLOALKANES AS M3 MUSCARINIC ACETYLCHOLIN RECEPTOR ANTAGONISTS
(FR) AZONIA BICYCLOALCANES COMME ANTAGONISTES DU RÉCEPTEUR D'ACÉTYLCHOLINE MUSCARINIQUE M3
Abstract:
(EN) This invention relates to M3 antagonists of formula (I): wherein R2, R4, R5, R6, W, V, A, D, X, t, u and v are as defined herein; pharmaceutical compositions containing them; methods for their preparation; and their use in the treatment of diseases where enhanced M3 receptor activation is implicated.
(FR) L'invention concerne des antagonistes M3 de formule (I): dans laquelle R2, R4, R5, R6, W, V, A, D, X, t, u et v sont tels que définis dans le descriptif; des compositions pharmaceutiques les contenant; leurs procédés de préparation; et leur utilisation dans le traitement de maladies appelant l'activation renforcée du récepteur M3.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)