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Machine translation
1. (WO2009094427) 4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/094427    International Application No.:    PCT/US2009/031665
Publication Date: 30.07.2009 International Filing Date: 22.01.2009
IPC:
C07D 401/12 (2006.01), C07D 213/74 (2006.01), C07D 213/63 (2006.01), A61K 31/4427 (2006.01), A61P 35/00 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; P.O. Box 4000, Route 206 and ProvinceLine Road, Princeton, New Jersey 08543-4000 (US) (For All Designated States Except US).
LIVINGSTON, Robert C. [US/US]; (US) (For US Only).
GALLAGHER, William P. [US/US]; (US) (For US Only)
Inventors: LIVINGSTON, Robert C.; (US).
GALLAGHER, William P.; (US)
Agent: GREENBLATT, Gary D.; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, New Jersey 08543-4000 (US)
Priority Data:
61/022,848 23.01.2008 US
61/121,931 12.12.2008 US
Title (EN) 4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER
(FR) PROCÉDÉ DE PRÉPARATION DE COMPOSÉS DE PYRIDINONE
Abstract: front page image
(EN)Disclosed herein is a process for preparing a compound of Formula (I), comprising the steps of: (a) reacting an aniline compound of Formula (II) and an carboxylic acid compound of Formula (III) or an activated carboxylic acid compound thereof, to provide a compound of Formula (IV); and (b) converting said protected amine group attached to said compound of Formula (IV) to an amine group to provide said compound of Formula (I); wherein PAm is a protected amine group. Processes to prepare the compounds of Formulae (II), (III), and (IV) are also disclosed.
(FR)L'invention porte sur un procédé de préparation d'un composé de Formule (I), comprenant les étapes consistant à : (a) faire réagir un composé d'aniline de Formule (II) et un composé acide carboxylique de Formule (III) ou un composé acide carboxylique activé de celui-ci, pour fournir un composé de Formule (IV); et (b) convertir ledit groupe amine protégé attaché audit composé de Formule (IV) en un groupe amine pour fournir ledit composé de Formule (I); PAm étant un groupe amine protégé. L'invention porte également sur des procédés de préparation des composés représentés par les Formules (II), (III) et (IV).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)