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1. (WO2009093972) ENANTIOMERICALLY PURE (-) 2-[1-(7-METHYL-2-(MORPHOLIN-4-YL)-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYLAMINO]BENZOIC ACID, ITS USE IN MEDICAL THERAPY, AND A PHARMACEUTICAL COMPOSITION COMPRISING IT - 026
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2009/093972 International Application No.: PCT/SE2009/050065
Publication Date: 30.07.2009 International Filing Date: 22.01.2009
IPC:
C07D 471/04 (2006.01) ,A61K 31/519 (2006.01) ,A61K 31/5377 (2006.01) ,A61P 11/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 7/02 (2006.01) ,A61P 9/10 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5375
1,4-Oxazines, e.g. morpholine
5377
not condensed and containing further heterocyclic rings, e.g. timolol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7
Drugs for disorders of the blood or the extracellular fluid
02
Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants:
ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje, SE (AllExceptUS)
FJELLSTRÖM, Ola [SE/SE]; SE (UsOnly)
GUSTAFSSON, David [SE/SE]; SE (UsOnly)
JACKSON, Shaun [AU/AU]; AU (UsOnly)
LINDBERG, Jan Å [SE/SE]; SE (UsOnly)
Inventors:
FJELLSTRÖM, Ola; SE
GUSTAFSSON, David; SE
JACKSON, Shaun; AU
LINDBERG, Jan Å; SE
Agent:
ASTRAZENECA AB; AstraZeneca Intellectual Property S-151 85 Södertälje, SE
Priority Data:
61/023,49825.01.2008US
Title (EN) ENANTIOMERICALLY PURE (-) 2-[1-(7-METHYL-2-(MORPHOLIN-4-YL)-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ETHYLAMINO]BENZOIC ACID, ITS USE IN MEDICAL THERAPY, AND A PHARMACEUTICAL COMPOSITION COMPRISING IT - 026
(FR) ACIDE (-)2-[1-(7-MÉTHYL-2-(MORPHOLIN-4-YL)-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-9-YL)ÉTHYLAMINO]BENZOÏQUE ÉNANTIOMÉRIQUEMENT PUR, SON UTILISATION EN THÉRAPIE MÉDICALE, ET COMPOSITION PHARMACEUTIQUE LE CONTENANT
Abstract:
(EN) The present invention relates to enantiomerically pure (-) 2-[1-(7-methyl-2-(morpholin-4-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9- yl)ethylamino]benzoic acid or pharmaceutically acceptable salts thereof, it being in a solid state, its use in medical therapy, pharmaceutical composition comprising it, its use in the preparation of a medicament for use in a method for preventing or treating diseases, and its use in method for preventing or treating disease. The present invention relates to a selective inhibitor of phosphoinositide (PI) 3-kinase β and use of the selective inhibitor in e.g. anti-thrombotic therapy.
(FR) La présente invention concerne concerne l'acide (-)2-[l-(7-méthyl-2-(morpholin-4-yl)-4-oxo-4H-pyrido[l,2-α]pyrimidin-9-yl)éthylamino]benzoïque énantiomériquement pur ou ses sels pharmaceutiquement acceptables, dans un état solide, son utilisation en thérapie médicale, une composition pharmaceutique le contenant, son utilisation pour la préparation d'un médicament destiné à être utilisé dans une méthode de prévention ou de traitement de maladies, et son utilisation dans une méthode de prévention ou de traitement d'une maladie. La présente invention concerne un inhibiteur sélectif de la phosphoinositide (PI) 3-kinase β et son utilisation, notamment dans un traitement anti-thrombotique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AR070236UY0001031609EP2245030JP2011510071MXMX/a/2010/008097RU2010133715
CN101925601CA2712022KR1020100118977BRPI0906805AU2009206804AU2012268829
IN5176/DELNP/2010