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1. (WO2009091550) SULFONE SUBSTITUTED 2,3-DIHYDROIMIDAZO [1,2-C] QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES WITH ANGIOGENESIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/091550    International Application No.:    PCT/US2009/000228
Publication Date: 23.07.2009 International Filing Date: 13.01.2009
IPC:
A61K 31/517 (2006.01)
Applicants: Bayer Schering Pharma AG [DE/DE]; Müllerstraβe, 178 13353 Berlin (DE) (For All Designated States Except US).
HENTEMANN, Martin, F. [US/US]; (US) (For US Only).
SCOTT, William [US/US]; (US) (For US Only).
WOOD, Jill [US/US]; (US) (For US Only).
JOHNSON, Jeffrey [US/US]; (US) (For US Only).
REDMAN, Aniko [US/US]; (US) (For US Only).
BULLION, Ann-marie [US/US]; (US) (For US Only).
GUERNON, Leatte [US/US]; (US) (For US Only)
Inventors: HENTEMANN, Martin, F.; (US).
SCOTT, William; (US).
WOOD, Jill; (US).
JOHNSON, Jeffrey; (US).
REDMAN, Aniko; (US).
BULLION, Ann-marie; (US).
GUERNON, Leatte; (US)
Agent: LOREN, Ralph, A.; Edwards Angell Palmer & Doge LLP P.O. Box 55874 Boston, MA 02205 (US)
Priority Data:
61/021,029 14.01.2008 US
Title (EN) SULFONE SUBSTITUTED 2,3-DIHYDROIMIDAZO [1,2-C] QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES WITH ANGIOGENESIS
(FR) DÉRIVÉS DE 2,3-DIHYDROIMIDAZO [1,2-C] QUINAZOLINE À SUBSTITUTION SULFONE UTILISÉS POUR TRAITER DES TROUBLES HYPERPROLIFÉRANTS ET DES MALADIES ASSOCIÉES À L'ANGIOGÉNÈSE
Abstract: front page image
(EN)This invention relates to novel sulfone 2I3-dihydroimidazo[1 l2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis mediated disorders, as a sole agent or in combination with other active ingredients.
(FR)Cette invention concerne des nouveaux composés 2,3-dihydroimidazo[1,2-c]quinazoline sulfone, des compositions pharmaceutiques contenant ces composés et l'utilisation de ces composés ou de ces compositions pour inhiber la phosphotidylinositol-3-kinase (PI3K) et traiter des maladies associées à l'activité de phosphotidylinositol-3-kinase (PI3K), en particulier, pour traiter des troubles hyperproliférants et/ou induits par l'angiogénèse, comme agent unique ou combinés avec d'autres ingrédients actifs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)