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1. (WO2009087474) AGONISTS FOR ANTIMICROBIAL PEPTIDE SYSTEMS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2009/087474 International Application No.: PCT/IB2008/003709
Publication Date: 16.07.2009 International Filing Date: 11.12.2008
Chapter 2 Demand Filed: 09.11.2009
IPC:
A23L 1/30 (2006.01) ,A61K 31/192 (2006.01) ,A61K 31/198 (2006.01) ,A61K 45/06 (2006.01) ,A61P 31/04 (2006.01) ,A61P 31/10 (2006.01) ,A61P 31/12 (2006.01) ,A61P 33/06 (2006.01)
A HUMAN NECESSITIES
23
FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
L
FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
1
Foods or foodstuffs; Their preparation or treatment
29
Modifying nutritive qualities of foods; Dietetic products
30
containing additives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
192
having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
197
the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198
Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10
Antimycotics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33
Antiparasitic agents
02
Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
06
Antimalarials
Applicants:
GUDMUNDSSON, Gudmundur, Hrafn [IS/IS]; IS (UsOnly)
AGERBERTH, Birgitta [SE/SE]; SE (UsOnly)
STEINGRIMSSON, Eirikur [IS/IS]; IS (UsOnly)
STROMBERG, Roger [SE/SE]; SE (UsOnly)
RAQIB, Rubhana [BD/BD]; BD (UsOnly)
AKTHELIA PHARMACEUTICALS [IS/IS]; Brekkugerdi 28 IS-108 Reykjavik, IS (AllExceptUS)
Inventors:
GUDMUNDSSON, Gudmundur, Hrafn; IS
AGERBERTH, Birgitta; SE
STEINGRIMSSON, Eirikur; IS
STROMBERG, Roger; SE
RAQIB, Rubhana; BD
Agent:
KREMER, Simon; Mewburn Ellis LLP 33 Gutter Lane London Greater London EC2V 8AS, GB
Priority Data:
61/019,65208.01.2008US
Title (EN) AGONISTS FOR ANTIMICROBIAL PEPTIDE SYSTEMS
(FR) AGONISTES POUR DES SYSTÈMES PEPTIDIQUES ANTIMICROBIENS
Abstract:
(EN) Short chain fatty acids (SCFAs) and glycerol esters of SCFAs not previously used for that purpose are provided for use as a medicament for treating, preventing or counteracting microbial infections in animals, including humans, by stimulating the innate antimicrobial peptide defense system. Preferred compounds include phenyl substituted short chain fatty acids (SCFAs) derivatives and. Also provided are methods and compositions for treating, preventing or counteracting microbial infections, including bacterial, viral, fungal, and parasitic infections, by administration of medicaments comprising a secretagogue-effective amount of the compounds of the invention.
(FR) Des acides gras à chaîne courte (SCFA) et des esters de glycérol et de SCFA non précédemment utilisés dans ce but sont proposés pour une utilisation en tant que médicament pour traiter, prévenir ou agir à l'encontre d'infections microbiennes chez les animaux, comprenant les êtres humains, par la stimulation du système de défense peptidique antimicrobien inné. Les composés préférés comprennent des dérivés d'acides gras à chaîne courte substitués par phényle (SCFA). L'invention porte également sur des procédés et des compositions pour traiter, prévenir ou agir à l'encontre d'infections microbiennes, comprenant des infections bactériennes, virales, fongiques et parasitiques, par l'administration de médicaments comprenant une quantité efficace de sécrétagogue des composés de l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)