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1. (WO2009087474) AGONISTS FOR ANTIMICROBIAL PEPTIDE SYSTEMS

Pub. No.:    WO/2009/087474    International Application No.:    PCT/IB2008/003709
Publication Date: Fri Jul 17 01:59:59 CEST 2009 International Filing Date: Fri Dec 12 00:59:59 CET 2008
IPC: A23L 1/30
A61K 31/192
A61K 31/198
A61K 45/06
A61P 31/04
A61P 31/10
A61P 31/12
A61P 33/06
Applicants: AKTHELIA PHARMACEUTICALS
GUDMUNDSSON, Gudmundur, Hrafn
AGERBERTH, Birgitta
STEINGRIMSSON, Eirikur
STROMBERG, Roger
RAQIB, Rubhana
Inventors: GUDMUNDSSON, Gudmundur, Hrafn
AGERBERTH, Birgitta
STEINGRIMSSON, Eirikur
STROMBERG, Roger
RAQIB, Rubhana
Title: AGONISTS FOR ANTIMICROBIAL PEPTIDE SYSTEMS
Abstract:
Short chain fatty acids (SCFAs) and glycerol esters of SCFAs not previously used for that purpose are provided for use as a medicament for treating, preventing or counteracting microbial infections in animals, including humans, by stimulating the innate antimicrobial peptide defense system. Preferred compounds include phenyl substituted short chain fatty acids (SCFAs) derivatives and. Also provided are methods and compositions for treating, preventing or counteracting microbial infections, including bacterial, viral, fungal, and parasitic infections, by administration of medicaments comprising a secretagogue-effective amount of the compounds of the invention.