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1. (WO2009085983) 5-ANILINOIMIDAZOPYRIDINES AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2009/085983 International Application No.: PCT/US2008/087482
Publication Date: 09.07.2009 International Filing Date: 18.12.2008
IPC:
C07D 471/04 (2006.01) ,C07D 487/04 (2006.01) ,A61K 31/437 (2006.01) ,A61K 31/4985 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985
Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
PRICE, Stephen [GB/GB]; GB (UsOnly)
HEALD, Robert [GB/GB]; GB (UsOnly)
LEE, Wendy [US/US]; US (UsOnly)
ZAK, Mark E. [CA/US]; US (UsOnly)
HEWITT, Joanne, Frances, Mary [GB/GB]; GB (UsOnly)
GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080, US (AllExceptUS)
Inventors:
PRICE, Stephen; GB
HEALD, Robert; GB
LEE, Wendy; US
ZAK, Mark E.; US
HEWITT, Joanne, Frances, Mary; GB
Agent:
WANG, Min; Genentech, Inc. 1 DNA Way, MS-49 South San Francisco, California 94080, US
Priority Data:
61/015,12919.12.2007US
61/054,01416.05.2008US
Title (EN) 5-ANILINOIMIDAZOPYRIDINES AND METHODS OF USE
(FR) 5-ANILINOIMIDAZOPYRIDINES ET PROCÉDÉS D'UTILISATION
Abstract:
(EN) The invention relates to imidazopyridines of formula I with anti-cancer and/or anti-inflammatory activity and more specifically to imidazopyridines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
(FR) L'invention concerne des imidazopyridines de la formule I ayant une activité anticancéreuse et/ou anti-inflammatoire, et plus précisément des imidazopyridines qui empêchent une activité de kinase MEK. L'invention concerne des compositions et des procédés utiles pour inhiber une croissance cellulaire anormale ou pour traiter un trouble hyper prolifératif ou une maladie inflammatoire chez un mammifère. L'invention concerne également des procédés d'utilisation de composés pour un diagnostic ou un traitement in vitro, in situ et in vivo de cellules de mammifère, ou de conditions pathologiques associées.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)