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1. WO2009085980 - 8-ANILIN0IMIDAZ0PYRIDINES AND THEIR USE AS ANTI-CANCER AND/OR ANTI-INFLAMMATORY AGENTS

Publication Number WO/2009/085980
Publication Date 09.07.2009
International Application No. PCT/US2008/087476
International Filing Date 18.12.2008
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C07D 471/04 (2006.01)
C07D 487/04 (2006.01)
A61K 31/437 (2006.01)
A61P 35/00 (2006.01)
CPC
C07D 471/04
C07D 487/04
Applicants
  • GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080, US (AllExceptUS)
  • PRICE, Stephen [GB/GB]; GB (UsOnly)
  • HEALD, Robert [GB/GB]; GB (UsOnly)
  • SAVY, Pascal Pierre Alexandre [FR/GB]; GB (UsOnly)
Inventors
  • PRICE, Stephen; GB
  • HEALD, Robert; GB
  • SAVY, Pascal Pierre Alexandre; GB
Agents
  • WANG, Min; Genentech, Inc. 1 DNA Way, MS-49 South San Francisco, California 94080, US
Priority Data
61/015,15519.12.2007US
61/054,02416.05.2008US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 8-ANILIN0IMIDAZ0PYRIDINES AND THEIR USE AS ANTI-CANCER AND/OR ANTI-INFLAMMATORY AGENTS
(FR) 8-ANILINOIMIDAZOPYRIDINES ET LEUR UTILISATION EN TANT QU'AGENTS ANTICANCÉREUX ET/OU ANTI-INFLAMMATOIRES
Abstract
(EN)
The invention relates to imidazopyridines of formula I with anti -cancer and/or anti- inflammatory activity and more specifically to imidazopyridines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperprolif erative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. (Formula I)
(FR)
L'invention concerne des imidazopyridines de la formule I ayant une activité anticancéreuse et/ou anti-inflammatoire et plus précisément des imidazopyridines qui empêchent une activité de kinase de MEK. L'invention concerne des compositions et des procédés utiles pour inhiber une croissance cellulaire anormale, ou pour traiter un trouble hyper prolifératif ou une maladie inflammatoire chez un mammifère. L'invention concerne également des procédés d'utilisation des composés pour un diagnostic ou un traitement in vitro, in situ et in vivo de cellules de mammifère, ou de conditions pathologiques associées. (Formule I).
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