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1. WO2009082687 - AZAINDOLIZINES AND METHODS OF USE

Publication Number WO/2009/082687
Publication Date 02.07.2009
International Application No. PCT/US2008/087626
International Filing Date 19.12.2008
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985
Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C07D 487/04 (2006.01)
A61K 31/437 (2006.01)
A61K 31/4985 (2006.01)
A61P 35/00 (2006.01)
CPC
C07D 487/04
Applicants
  • GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080, US (AllExceptUS)
  • PRICE, Stephen [GB/GB]; GB (UsOnly)
  • HEALD, Robert [GB/GB]; GB (UsOnly)
  • HEWITT, Peter [GB/GB]; GB (UsOnly)
Inventors
  • PRICE, Stephen; GB
  • HEALD, Robert; GB
  • HEWITT, Peter; GB
Agents
  • WANG, Min; 1 DNA Way MS 49 South San Francisco, California 94080, US
Priority Data
61/015,94221.12.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) AZAINDOLIZINES AND METHODS OF USE
(FR) AZAINDOLIZINES ET PROCÉDÉS D'UTILISATION
Abstract
(EN)
The invention relates to azaindolizines of formula I-a or I-b with anti-cancer and/or anti-inflammatory activity and more specifically to azaindolizines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
(FR)
L'invention concerne des azaindolizines de formule I-a ou I-b présentant une activité anticancéreuse et/ou anti-inflammatoire et plus spécifiquement des azaindolizines qui inhibent l'activité MEK kinase. L'invention propose des compositions et des procédés utiles pour inhiber la prolifération cellulaire anormale ou traiter un trouble hyperprolifératif, ou pour traiter une pathologie inflammatoire chez un mammifère. L'invention concerne également des procédés d'utilisation des composés pour le diagnostic ou le traitement in vitro, in situ et in vivo de cellules de mammifère, ou des états pathologiques associés.
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