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1. (WO2009081105) QUINOXALINE AND QUINOLINE DERIVATIVES AS KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2009/081105 International Application No.: PCT/GB2008/004171
Publication Date: 02.07.2009 International Filing Date: 17.12.2008
IPC:
C07D 401/14 (2006.01) ,C07D 403/06 (2006.01) ,C07D 403/12 (2006.01) ,C07D 403/14 (2006.01) ,C07D 409/14 (2006.01) ,C07D 413/14 (2006.01) ,C07D 473/34 (2006.01) ,C07D 473/36 (2006.01) ,A61K 31/395 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
26
with an oxygen, sulfur, or nitrogen atom directly attached in position 2 or 6, but not in both
32
Nitrogen atom
34
attached in position 6, e.g. adenine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
26
with an oxygen, sulfur, or nitrogen atom directly attached in position 2 or 6, but not in both
36
Sulfur atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
ALLEN, Daniel, Rees [GB/GB]; GB (UsOnly)
BUCKLEY, George, Martin [GB/GB]; GB (UsOnly)
BÜRLI, Roland [CH/GB]; GB (UsOnly)
DAVENPORT, Richard, John [GB/GB]; GB (UsOnly)
KINSELLA, Natasha [GB/GB]; GB (UsOnly)
LOCK, Christopher, James [GB/GB]; GB (UsOnly)
LOWE, Christopher [GB/GB]; GB (UsOnly)
MACK, Stephen, Robert [GB/GB]; GB (UsOnly)
PITT, William, Ross [GB/GB]; GB (UsOnly)
RATCLIFFE, Andrew, James [GB/GB]; GB (UsOnly)
RICHARD, Marianna, Dilani [GB/GB]; GB (UsOnly)
SABIN, Verity, Margaret [GB/GB]; GB (UsOnly)
SHARPE, Andrew [GB/GB]; GB (UsOnly)
TAIT, Laura, Jane [GB/GB]; GB (UsOnly)
WARRELOW, Graham, John [GB/GB]; GB (UsOnly)
WILLIAMS, Sophie, Caroline [GB/GB]; GB (UsOnly)
UCB PHARMA S.A. [BE/BE]; 60 Allée de la Recherche B-1070 Brussels, BE (AllExceptUS)
Inventors:
ALLEN, Daniel, Rees; GB
BUCKLEY, George, Martin; GB
BÜRLI, Roland; GB
DAVENPORT, Richard, John; GB
KINSELLA, Natasha; GB
LOCK, Christopher, James; GB
LOWE, Christopher; GB
MACK, Stephen, Robert; GB
PITT, William, Ross; GB
RATCLIFFE, Andrew, James; GB
RICHARD, Marianna, Dilani; GB
SABIN, Verity, Margaret; GB
SHARPE, Andrew; GB
TAIT, Laura, Jane; GB
WARRELOW, Graham, John; GB
WILLIAMS, Sophie, Caroline; GB
Agent:
THOMPSON, John; UCB CELLTECH 208 Bath Road Slough Berkshire SL1 3WE, GB
Priority Data:
0725030.121.12.2007GB
0815177.119.08.2008GB
Title (EN) QUINOXALINE AND QUINOLINE DERIVATIVES AS KINASE INHIBITORS
(FR) DÉRIVÉS DE QUINOXALINE ET DE QUINOLÉINE EN TANT QU'INHIBITEURS DE KINASE
Abstract:
(EN) A series of heteroaryl-substituted quinoxaline and quinoline derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.
(FR) La présente invention propose une série de dérivés de quinoxaline et de quinoléine substitués par un hétéroaryle. Lesdits dérivés sont des inhibiteurs sélectifs d'enzymes kinase PI3, et sont en conséquence utiles en médecine, par exemple dans le traitement de pathologies inflammatoires, auto-immunes, cardiovasculaires, neurodégénératives, métaboliques, oncologiques, nociceptives ou ophtalmiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)