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1. WO2009081105 - QUINOXALINE AND QUINOLINE DERIVATIVES AS KINASE INHIBITORS

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Publication Number WO/2009/081105
Publication Date 02.07.2009
International Application No. PCT/GB2008/004171
International Filing Date 17.12.2008
IPC
C07D 401/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 403/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 403/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 403/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14containing three or more hetero rings
C07D 409/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14containing three or more hetero rings
C07D 413/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 27/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
Applicants
  • UCB PHARMA S.A. [BE]/[BE] (AllExceptUS)
  • ALLEN, Daniel, Rees [GB]/[GB] (UsOnly)
  • BUCKLEY, George, Martin [GB]/[GB] (UsOnly)
  • BÜRLI, Roland [CH]/[GB] (UsOnly)
  • DAVENPORT, Richard, John [GB]/[GB] (UsOnly)
  • KINSELLA, Natasha [GB]/[GB] (UsOnly)
  • LOCK, Christopher, James [GB]/[GB] (UsOnly)
  • LOWE, Christopher [GB]/[GB] (UsOnly)
  • MACK, Stephen, Robert [GB]/[GB] (UsOnly)
  • PITT, William, Ross [GB]/[GB] (UsOnly)
  • RATCLIFFE, Andrew, James [GB]/[GB] (UsOnly)
  • RICHARD, Marianna, Dilani [GB]/[GB] (UsOnly)
  • SABIN, Verity, Margaret [GB]/[GB] (UsOnly)
  • SHARPE, Andrew [GB]/[GB] (UsOnly)
  • TAIT, Laura, Jane [GB]/[GB] (UsOnly)
  • WARRELOW, Graham, John [GB]/[GB] (UsOnly)
  • WILLIAMS, Sophie, Caroline [GB]/[GB] (UsOnly)
Inventors
  • ALLEN, Daniel, Rees
  • BUCKLEY, George, Martin
  • BÜRLI, Roland
  • DAVENPORT, Richard, John
  • KINSELLA, Natasha
  • LOCK, Christopher, James
  • LOWE, Christopher
  • MACK, Stephen, Robert
  • PITT, William, Ross
  • RATCLIFFE, Andrew, James
  • RICHARD, Marianna, Dilani
  • SABIN, Verity, Margaret
  • SHARPE, Andrew
  • TAIT, Laura, Jane
  • WARRELOW, Graham, John
  • WILLIAMS, Sophie, Caroline
Agents
  • THOMPSON, John
Priority Data
0725030.121.12.2007GB
0815177.119.08.2008GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) QUINOXALINE AND QUINOLINE DERIVATIVES AS KINASE INHIBITORS
(FR) DÉRIVÉS DE QUINOXALINE ET DE QUINOLÉINE EN TANT QU'INHIBITEURS DE KINASE
Abstract
(EN) A series of heteroaryl-substituted quinoxaline and quinoline derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.
(FR) La présente invention propose une série de dérivés de quinoxaline et de quinoléine substitués par un hétéroaryle. Lesdits dérivés sont des inhibiteurs sélectifs d'enzymes kinase PI3, et sont en conséquence utiles en médecine, par exemple dans le traitement de pathologies inflammatoires, auto-immunes, cardiovasculaires, neurodégénératives, métaboliques, oncologiques, nociceptives ou ophtalmiques.
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