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1. (WO2009080766) METHOD FOR MANUFACTURING AND APPLICATION OF RANDOM ORDERED ARRAYS OF CHEMICAL COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2009/080766 International Application No.: PCT/EP2008/068056
Publication Date: 02.07.2009 International Filing Date: 19.12.2008
IPC:
B01J 19/00 (2006.01) ,C40B 20/02 (2006.01) ,C40B 30/04 (2006.01) ,C40B 50/18 (2006.01)
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
J
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS, COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19
Chemical, physical, or physico-chemical processes in general; Their relevant apparatus
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
20
Methods specially adapted for identifying library members
02
Identifying library members by their fixed physical location on a support or substrate
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
30
Methods of screening libraries
04
by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
50
Methods of creating libraries, e.g. combinatorial synthesis
14
Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
18
using a particular method of attachment to the solid support
Applicants:
AUER, Manfred [AT/GB]; GB (UsOnly)
GSTACH, Hubert [AT/AT]; AT (UsOnly)
ROTH, Guenter [DE/DE]; DE (UsOnly)
WIESMUELLER, Karl-Heinz [DE/DE]; DE (UsOnly)
NOVARTIS AG [CH/CH]; Lichtstrasse 35 CH-4056 Basel, CH (AllExceptUS)
Inventors:
AUER, Manfred; GB
GSTACH, Hubert; AT
ROTH, Guenter; DE
WIESMUELLER, Karl-Heinz; DE
Agent:
BOURGAREL, Denis; Novartis Pharma AG Patent Department CH-4002 Basel, CH
Priority Data:
10 2007 062 154.120.12.2007DE
Title (EN) METHOD FOR MANUFACTURING AND APPLICATION OF RANDOM ORDERED ARRAYS OF CHEMICAL COMPOUNDS
(FR) PROCÉDÉ DE FABRICATION ET APPLICATION DE RÉSEAUX ORDONNÉS ALÉATOIRES DE COMPOSÉS CHIMIQUES
Abstract:
(EN) The presented invention describes a method for the efficient manufacturing and application of random ordered arrays of chemical compounds. The method involves the generation of a random ordered array of beads, each bearing exactly one chemical compound. The chemical compounds from the beads of the bead array, called master, are transferred to another surface, the assay plate, generating a chemical copy of the bead array onto this surface. The assay plate could be used like any microarray.
(FR) Cette invention concerne un procédé de fabrication et d'application efficaces de réseaux ordonnés aléatoires de composés chimiques. Le procédé implique la génération d'un réseau ordonné aléatoire de billes, chacune portant exactement un composé chimique. Les composés chimiques des billes du réseau de billes (matrice) sont transférés sur une autre surface (plaque de dosage) générant une copie chimique du réseau de billes sur cette surface. La plaque de dosage peut être utilisée comme n'importe quelle micromatrice.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)