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1. (WO2009080663) TRIAZOLE OXADIAZOLES DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2009/080663 International Application No.: PCT/EP2008/067776
Publication Date: 02.07.2009 International Filing Date: 17.12.2008
IPC:
C07D 413/04 (2006.01) ,C07D 413/14 (2006.01) ,A61K 31/4245 (2006.01) ,A61P 37/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4245
Oxadiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
Applicants:
QUATTROPANI, Anna [CH/CH]; CH (UsOnly)
CLEVA, Christophe [FR/FR]; FR (UsOnly)
SEBILLE, Eric [FR/FR]; FR (UsOnly)
SCHWARZ, Matthias [CH/CH]; CH (UsOnly)
MARIN, Delphine [FR/FR]; FR (UsOnly)
BOMBRUN, Agnès [CH/CH]; CH (UsOnly)
BLACKABY, Wesley [GB/GB]; GB (UsOnly)
BAKER-GLENN, Charles [GB/GB]; GB (UsOnly)
KNIGHT, Chris [GB/GB]; GB (UsOnly)
ROUSE, Craig [GB/GB]; GB (UsOnly)
MERCK SERONO S.A. [CH/CH]; Centre industriel CH-1267 Coinsins, CH (AllExceptUS)
Inventors:
QUATTROPANI, Anna; CH
CLEVA, Christophe; FR
SEBILLE, Eric; FR
SCHWARZ, Matthias; CH
MARIN, Delphine; FR
BOMBRUN, Agnès; CH
BLACKABY, Wesley; GB
BAKER-GLENN, Charles; GB
KNIGHT, Chris; GB
ROUSE, Craig; GB
Agent:
MERCK SERONO S.A. - GENEVA; Intellectual Property 9, chemin des Mines CH-1202 Geneva, CH
Priority Data:
07150311.421.12.2007EP
61/066,38520.02.2008US
Title (EN) TRIAZOLE OXADIAZOLES DERIVATIVES
(FR) DÉRIVÉS DE TRIAZOLES ET D'OXADIAZOLES
Abstract:
(EN) The invention relates to compounds of formula (I), wherein R1, R2, Ra, Rb, X have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
(FR) L'invention porte sur des composés de formule (I) dans laquelle: R1, R2, Ra, Rb, et X ont les significations données dans la revendication 1. Lesdits composés peuvent servir par exemple pour le traitement de troubles auto-immunes tels que la sclérose en plaques.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)