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1. WO2009080663 - TRIAZOLE OXADIAZOLES DERIVATIVES

Publication Number WO/2009/080663
Publication Date 02.07.2009
International Application No. PCT/EP2008/067776
International Filing Date 17.12.2008
IPC
C07D 413/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 413/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
A61K 31/4245 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4245Oxadiazoles
A61P 37/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
CPC
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 21/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
Applicants
  • MERCK SERONO S.A. [CH]/[CH] (AllExceptUS)
  • QUATTROPANI, Anna [CH]/[CH] (UsOnly)
  • CLEVA, Christophe [FR]/[FR] (UsOnly)
  • SEBILLE, Eric [FR]/[FR] (UsOnly)
  • SCHWARZ, Matthias [CH]/[CH] (UsOnly)
  • MARIN, Delphine [FR]/[FR] (UsOnly)
  • BOMBRUN, Agnès [CH]/[CH] (UsOnly)
  • BLACKABY, Wesley [GB]/[GB] (UsOnly)
  • BAKER-GLENN, Charles [GB]/[GB] (UsOnly)
  • KNIGHT, Chris [GB]/[GB] (UsOnly)
  • ROUSE, Craig [GB]/[GB] (UsOnly)
Inventors
  • QUATTROPANI, Anna
  • CLEVA, Christophe
  • SEBILLE, Eric
  • SCHWARZ, Matthias
  • MARIN, Delphine
  • BOMBRUN, Agnès
  • BLACKABY, Wesley
  • BAKER-GLENN, Charles
  • KNIGHT, Chris
  • ROUSE, Craig
Agents
  • MERCK SERONO S.A. - GENEVA
Priority Data
07150311.421.12.2007EP
61/066,38520.02.2008US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TRIAZOLE OXADIAZOLES DERIVATIVES
(FR) DÉRIVÉS DE TRIAZOLES ET D'OXADIAZOLES
Abstract
(EN) The invention relates to compounds of formula (I), wherein R1, R2, Ra, Rb, X have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis.
(FR) L'invention porte sur des composés de formule (I) dans laquelle: R1, R2, Ra, Rb, et X ont les significations données dans la revendication 1. Lesdits composés peuvent servir par exemple pour le traitement de troubles auto-immunes tels que la sclérose en plaques.
Latest bibliographic data on file with the International Bureau