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1. WO2009080248 - SUBSTITUTED 2-PHENYLPYRIMIDINE-5-CARBOXYLIC ACIDS AND THE USE THEREOF

Publication Number WO/2009/080248
Publication Date 02.07.2009
International Application No. PCT/EP2008/010698
International Filing Date 16.12.2008
IPC
C07D 239/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
C07D 239/34 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32One oxygen, sulfur or nitrogen atom
34One oxygen atom
A61K 31/505 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A61P 7/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
CPC
A61P 7/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
C07D 239/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
C07D 239/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32One oxygen, sulfur or nitrogen atom
34One oxygen atom
C07D 405/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
Applicants
  • BAYER SCHERING PHARMA AKTIENGESELLSCHAFT [DE]/[DE] (AllExceptUS)
  • BÄRFACKER, Lars [DE]/[DE] (UsOnly)
  • ALBRECHT-KÜPPER, Barbara [DE]/[DE] (UsOnly)
  • KOLKHOF, Peter [DE]/[DE] (UsOnly)
  • CANCHO GRANDE, Yolanda [ES]/[DE] (UsOnly)
  • NITSCHE, Adam [DE]/[DE] (UsOnly)
  • LUSTIG, Klemens [DE]/[DE] (UsOnly)
Inventors
  • BÄRFACKER, Lars
  • ALBRECHT-KÜPPER, Barbara
  • KOLKHOF, Peter
  • CANCHO GRANDE, Yolanda
  • NITSCHE, Adam
  • LUSTIG, Klemens
Common Representative
  • BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Priority Data
10 2007 061 757.920.12.2007DE
Publication Language German (de)
Filing Language German (DE)
Designated States
Title
(DE) SUBSTITUIERTE 2-PHENYLPYRIMIDIN-5-CARBONSÄUREN UND IHRE VERWENDUNG
(EN) SUBSTITUTED 2-PHENYLPYRIMIDINE-5-CARBOXYLIC ACIDS AND THE USE THEREOF
(FR) ACIDES 2-PHÉNYLPYRIMIDINE-5-CARBOXYLIQUES SUBSTITUÉS ET LEUR UTILISATION
Abstract
(DE) Die vorliegende Anmeldung betrifft neue substituierte 2-Phenylpyrimidin-5-carbonsäure-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, vorzugsweise zur Behandlung und/oder Prophylaxe kardiovaskulärer Erkrankungen, insbesondere von Dyslipidämien, Arteriosklerose und Herzinsuffizienz.
(EN) The present application relates to novel substituted 2-phenylpyrimidine-5-carboxylic acid derivatives, a method for the production thereof and to use thereof for the treatment and/or prophylaxis of diseases and to the use thereof for the production of pharmaceuticals for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular diseases, particularly dyslipidemia, arteriosclerosis and cardiac insufficiency.
(FR) L'invention concerne de nouveaux dérivés d'acide 2-phénylpyrimidine-5-carboxylique, leur procédé de production, leur utilisation pour le traitement et/ou la prophylaxie de maladies, ainsi que leur utilisation pour la production de médicaments destinés au traitement et/ou à la prophylaxie de maladies, de préférence, au traitement et/ou à la prophylaxie de maladies cardiovasculaires, en particulier de dyslipidémies, d'artériosclérose et d'insuffisance cardiaque.
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