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1. WO2009078973 - MICROBIAL CONVERSION OF OILS AND FATTY ACIDS TO HIGH-VALUE CHEMICALS

Publication Number WO/2009/078973
Publication Date 25.06.2009
International Application No. PCT/US2008/013707
International Filing Date 15.12.2008
IPC
C12N 15/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
CPC
C12N 1/20
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof
20Bacteria
C12P 13/001
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13Preparation of nitrogen-containing organic compounds
001Amines; Imines
C12P 17/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
02Oxygen as only ring hetero atoms
04containing a five-membered hetero ring, e.g. griseofulvin ; , vitamin C
C12P 7/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
02containing a hydroxy group
04acyclic
C12P 7/065
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
02containing a hydroxy group
04acyclic
06Ethanol, i.e. non-beverage
065with microorganisms other than yeasts
C12P 7/16
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
02containing a hydroxy group
04acyclic
16Butanols
Applicants
  • GLYCOS BIOTECHNOLOGIES, INCORPORATED [US]/[US] (AllExceptUS)
  • CAMPBELL, Paul [US]/[US] (UsOnly)
  • GONZALEZ, Ramon [US]/[US] (UsOnly)
Inventors
  • CAMPBELL, Paul
  • GONZALEZ, Ramon
Agents
  • HIBLER, David, W.
Priority Data
61/007,48113.12.2007US
61/189,42719.08.2008US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MICROBIAL CONVERSION OF OILS AND FATTY ACIDS TO HIGH-VALUE CHEMICALS
(FR) CONVERSION MICROBIENNE D'HUILES ET ACIDES GRAS EN PRODUITS CHIMIQUES DE GRANDE VALEUR
Abstract
(EN)
Microorganisms for the production of high-value chemicals from free fatty acids are provided. The microorganisms comprise genetic mutations that alter fatty acid metabolism. The genetic mutations include a mutation or deletion of a fadR gene in which the FadR enzyme activity is partially or substantially eliminated and a mutation in an atoC gene that provides overexpression of the microorganism's ato operon. Methods of using the microorganisms to produce high-value chemicals are also provided. The high-value chemicals include ethanol, methyl acetate, succinate, gamma-butyrolactone, 1,4-butanediol, acetone, isopropanol, butyrate, butanol, mevalonate, propionate, ethanolamine and 1,2-propanediol.
(FR)
L'invention concerne des microorganismes pour la production de produits chimiques de grande valeur à partir d'acides gras libres. Les microorganismes comprennent des mutations génétiques qui modifient le métabolisme des acides gras. Les mutations génétiques comprennent une mutation ou délétion d'un gène fadR dans lequel l'activité enzymatique de FadR est partiellement ou en grande partie éliminée et une mutation dans un gène atoC qui permet la surexpression de l'opéron ato du microorganisme. L'invention concerne également des procédés d'utilisation des microorganismes pour produire des produits chimiques de grande valeur. Ces produits chimiques de grande valeur comprennent l'éthanol, l'acétate de méthyle, un succinate, la gamma-butyrolactone, le 1,4-butanediol, l'acétone, l'isopropanol, un butyrate, le butanol, un mévalonate, un propionate, l'éthanolamine et le 1,2-propanediol.
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