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1. WO2009071901 - A SUBSTITUTED THIENO-PYRIDINONE KINASE INHIBITOR

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Publication Number WO/2009/071901
Publication Date 11.06.2009
International Application No. PCT/GB2008/004018
International Filing Date 03.12.2008
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
4365
the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
C07D 495/04 (2006.01)
A61K 31/4365 (2006.01)
A61P 29/00 (2006.01)
CPC
C07D 495/04
Applicants
  • UCB PHARMA S.A. [BE/BE]; 60 Allée de la Recherche B-1070 Brussels, BE (AllExceptUS)
  • SHARPE, Andrew [GB/GB]; GB (UsOnly)
Inventors
  • SHARPE, Andrew; GB
Agents
  • THOMPSON, John; UCB Celltech 208 Bath Road Slough Berkshire SL1 3WE, GB
Priority Data
0723748.004.12.2007GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A SUBSTITUTED THIENO-PYRIDINONE KINASE INHIBITOR
(FR) INHIBITEUR DE KINASE DE TYPE THIÉNO-PYRIDINONE SUBSTITUÉE
front page image
Abstract
(EN)
3- {2-[2-Fluoro-5-(morpholin-4-ylcarbonyl)phenyl]-pyridin-4-yl}-5,5-dimethyl-2-(morpholin-4-yl)-5,6-dihydrothieno[2.3-c]pyridin-7(4H)-one, or a pharmaceutically acceptable salt or solvate thereof, being a selective inhibitor of PD kinase enzymes, is accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions. (I)
(FR)
La présente invention concerne la 3-{2-[2-Fluoro-5-(morpholin-4-ylcarbonyl)phenyl]-pyridin-4-yl}-5,5-dimethyl-2-(morpholin-4-yl)-5,6-dihydrothieno[2.3-c]pyridin-7(4H)-one, ou un sel ou un solvate pharmaceutiquement acceptables de celle-ci, qui est un inhibiteur sélectif des enzymes PD kinase, qui est obtenue de sorte à être bénéfique en médecine, par exemple dans le traitement d'états inflammatoires, auto-immuns, cardiovasculaires, neurodégénératifs, métaboliques, oncologiques, nociceptifs ou ophtalmiques.
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