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1. WO2009071901 - A SUBSTITUTED THIENO-PYRIDINONE KINASE INHIBITOR

Publication Number WO/2009/071901
Publication Date 11.06.2009
International Application No. PCT/GB2008/004018
International Filing Date 03.12.2008
IPC
C07D 495/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/4365 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
4365the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
CPC
C07D 495/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • UCB PHARMA S.A. [BE]/[BE] (AllExceptUS)
  • SHARPE, Andrew [GB]/[GB] (UsOnly)
Inventors
  • SHARPE, Andrew
Agents
  • THOMPSON, John
Priority Data
0723748.004.12.2007GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) A SUBSTITUTED THIENO-PYRIDINONE KINASE INHIBITOR
(FR) INHIBITEUR DE KINASE DE TYPE THIÉNO-PYRIDINONE SUBSTITUÉE
Abstract
(EN) 3- {2-[2-Fluoro-5-(morpholin-4-ylcarbonyl)phenyl]-pyridin-4-yl}-5,5-dimethyl-2-(morpholin-4-yl)-5,6-dihydrothieno[2.3-c]pyridin-7(4H)-one, or a pharmaceutically acceptable salt or solvate thereof, being a selective inhibitor of PD kinase enzymes, is accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions. (I)
(FR) La présente invention concerne la 3-{2-[2-Fluoro-5-(morpholin-4-ylcarbonyl)phenyl]-pyridin-4-yl}-5,5-dimethyl-2-(morpholin-4-yl)-5,6-dihydrothieno[2.3-c]pyridin-7(4H)-one, ou un sel ou un solvate pharmaceutiquement acceptables de celle-ci, qui est un inhibiteur sélectif des enzymes PD kinase, qui est obtenue de sorte à être bénéfique en médecine, par exemple dans le traitement d'états inflammatoires, auto-immuns, cardiovasculaires, neurodégénératifs, métaboliques, oncologiques, nociceptifs ou ophtalmiques.
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