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1. (WO2009071895) FUSED THIAZOLE AND THIOPHENE DERIVATIVES AS KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2009/071895 International Application No.: PCT/GB2008/004011
Publication Date: 11.06.2009 International Filing Date: 03.12.2008
IPC:
C07D 495/04 (2006.01) ,A61K 31/4365 (2006.01) ,A61P 29/00 (2006.01) ,C07D 417/14 (2006.01) ,C07D 513/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
4365
the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
513
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
KINSELLA, Natasha [GB/GB]; GB (UsOnly)
LOWE, Christopher [GB/GB]; GB (UsOnly)
MORGAN, Trevor [GB/GB]; GB (UsOnly)
PERRY, Benjamin Garfield [GB/GB]; GB (UsOnly)
SABIN, Verity Margaret [GB/GB]; GB (UsOnly)
SHARPE, Andrew [GB/GB]; GB (UsOnly)
UCB PHARMA S.A. [BE/BE]; 60 Allée de la Recherche B-1070 Brussels, BE (AllExceptUS)
Inventors:
KINSELLA, Natasha; GB
LOWE, Christopher; GB
MORGAN, Trevor; GB
PERRY, Benjamin Garfield; GB
SABIN, Verity Margaret; GB
SHARPE, Andrew; GB
Agent:
THOMPSON, John; UCB Celltech 208 Bath Road Slough Berkshire SL1 3WE, GB
Priority Data:
0723748.004.12.2007GB
0723749.804.12.2007GB
Title (EN) FUSED THIAZOLE AND THIOPHENE DERIVATIVES AS KINASE INHIBITORS
(FR) DÉRIVÉS THIAZOLE ET THIOPHÈNE FUSIONNÉS COMME INHIBITEURS DE KINASE
Abstract:
(EN) A series of fused bicyclic thiazole and thiophene derivatives which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, and in the 4-position by hydroxy, oxo or an amine moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions. (I)
(FR) La présente invention concerne une série de dérivés thiazole et thiophène bicycliques fusionnés qui sont substitués en position 2 par un groupement morpholin-4-yle éventuellement substitué, et en position 4 par un groupement hydroxy, oxo ou amine, qui sont des inhibiteurs sélectifs des enzymes PI3 kinase, qui sont obtenus de sorte à être bénéfiques en médecine, par exemple dans le traitement d'états inflammatoires, auto-immuns, cardiovasculaires, neurodégénératifs, métaboliques, oncologiques, nociceptifs ou ophtalmiques. (I)
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)