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1. WO2009071895 - FUSED THIAZOLE AND THIOPHENE DERIVATIVES AS KINASE INHIBITORS

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Publication Number WO/2009/071895
Publication Date 11.06.2009
International Application No. PCT/GB2008/004011
International Filing Date 03.12.2008
IPC
C07D 495/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/4365 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
4365the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
C07D 417/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14containing three or more hetero rings
C07D 513/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
513Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
C07D 417/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
14containing three or more hetero rings
C07D 495/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 513/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
513Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • UCB PHARMA S.A. [BE]/[BE] (AllExceptUS)
  • KINSELLA, Natasha [GB]/[GB] (UsOnly)
  • LOWE, Christopher [GB]/[GB] (UsOnly)
  • MORGAN, Trevor [GB]/[GB] (UsOnly)
  • PERRY, Benjamin Garfield [GB]/[GB] (UsOnly)
  • SABIN, Verity Margaret [GB]/[GB] (UsOnly)
  • SHARPE, Andrew [GB]/[GB] (UsOnly)
Inventors
  • KINSELLA, Natasha
  • LOWE, Christopher
  • MORGAN, Trevor
  • PERRY, Benjamin Garfield
  • SABIN, Verity Margaret
  • SHARPE, Andrew
Agents
  • THOMPSON, John
Priority Data
0723748.004.12.2007GB
0723749.804.12.2007GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) FUSED THIAZOLE AND THIOPHENE DERIVATIVES AS KINASE INHIBITORS
(FR) DÉRIVÉS THIAZOLE ET THIOPHÈNE FUSIONNÉS COMME INHIBITEURS DE KINASE
front page image
Abstract
(EN) A series of fused bicyclic thiazole and thiophene derivatives which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, and in the 4-position by hydroxy, oxo or an amine moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions. (I)
(FR) La présente invention concerne une série de dérivés thiazole et thiophène bicycliques fusionnés qui sont substitués en position 2 par un groupement morpholin-4-yle éventuellement substitué, et en position 4 par un groupement hydroxy, oxo ou amine, qui sont des inhibiteurs sélectifs des enzymes PI3 kinase, qui sont obtenus de sorte à être bénéfiques en médecine, par exemple dans le traitement d'états inflammatoires, auto-immuns, cardiovasculaires, neurodégénératifs, métaboliques, oncologiques, nociceptifs ou ophtalmiques. (I)
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