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1. WO2009068885 - DINUCLEAR, QUADRUPLY-STRANDED COMPOUNDS COMPRISING PALLADIUM OR PLATINUM

Publication Number WO/2009/068885
Publication Date 04.06.2009
International Application No. PCT/GB2008/003967
International Filing Date 28.11.2008
IPC
C07F 15/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
15Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
C07D 213/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
C07D 213/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
24with substituted hydrocarbon radicals attached to ring carbon atoms
28Radicals substituted by singly-bound oxygen or sulfur atoms
30Oxygen atoms
CPC
C07D 213/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
C07D 213/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
24with substituted hydrocarbon radicals attached to ring carbon atoms
28Radicals substituted by singly-bound oxygen or sulfur atoms
30Oxygen atoms
Applicants
  • THE UNIVERSITY OF BIRMINGHAM [GB]/[GB] (AllExceptUS)
  • HANNON, Michael, J. [GB]/[GB] (UsOnly)
Inventors
  • HANNON, Michael, J.
Agents
  • ELSY, David
Priority Data
0723503.930.11.2007GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DINUCLEAR, QUADRUPLY-STRANDED COMPOUNDS COMPRISING PALLADIUM OR PLATINUM
(FR) TRAITEMENT CONTRE LE CANCER
Abstract
(EN)
The invention relates to a compound of formula (M2L4 where: M = a palladium or platinum metal ion; L = X = -O-, -S-, -NH-, or (-CH2-)n, where n = 1, 2 or 3; R2, R4, R5, R6 are each independently selected from -H, -F, -Cl, -Br, -I, -methyl, -ethyl, -propyl, -O-methyl, -OH, -CH2OH, and - CH2CH2OH, R7, R8, R9, R10 are each independently selected from -H, -F, -Cl, -Br, -I, - methyl, -ethyl, -propyl and -O-methyl; a pharmaceutically acceptable salt, complex thereof, compositions comprising the compound or complex. The invention further relates to the use of the compound or composition in the treatment of a cancer, a microbial infection or a virus infection, to a method of treating a cancer, a microbial infection or a viral infection comprising administering to a patient a pharmaceutically acceptable amount of the compound or composition.
(FR)
L'invention concerne un composé de formule 1 (M2L4) dans laquelle : M = un ion métallique palladium ou platine; L = X = -O-, -S-, -NH-, ou (-CH2-)n, où n = 1, 2 ou 3; R2, R4, R5, R6 sont chacun indépendamment choisis parmi -H, -F, -Cl, -Br, -I, -méthyle, -éthyle, -propyle, -O-méthyle, -OH, -CH2OH, et - CH2CH2OH, R7, R8, R9, R10 sont chacun indépendamment choisis parmi -H, -F, -Cl, -Br, -I, -méthyle, -éthyle, -propyle et -O-méthyle; un sel pharmaceutiquement acceptable, un complexe de celui-ci, des compositions comprenant le composé ou le complexe. L'invention concerne en outre l'utilisation du composé ou de la composition dans le traitement d'un cancer, d'une infection microbienne ou d'une infection virale, un procédé de traitement d'un cancer, d'une infection microbienne ou d'une infection virale comprenant l'administration à un patient d'une quantité pharmaceutiquement acceptable du composé ou de la composition.
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