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1. (WO2009068885) DINUCLEAR, QUADRUPLY-STRANDED COMPOUNDS COMPRISING PALLADIUM OR PLATINUM
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2009/068885 International Application No.: PCT/GB2008/003967
Publication Date: 04.06.2009 International Filing Date: 28.11.2008
IPC:
C07F 15/00 (2006.01) ,C07D 213/06 (2006.01) ,C07D 213/30 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
15
Compounds containing elements of the 8th Group of the Periodic System
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06
containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
24
with substituted hydrocarbon radicals attached to ring carbon atoms
28
Radicals substituted by singly-bound oxygen or sulfur atoms
30
Oxygen atoms
Applicants:
THE UNIVERSITY OF BIRMINGHAM [GB/GB]; Institute of Research & Development Birmingham Research Park Vincent Drive Birmingham B15 2SQ, GB (AllExceptUS)
HANNON, Michael, J. [GB/GB]; GB (UsOnly)
Inventors:
HANNON, Michael, J.; GB
Agent:
ELSY, David ; Withers & Rogers LLP Goldings House 2 Hays Lane London SE1 2HW, GB
Priority Data:
0723503.930.11.2007GB
Title (EN) DINUCLEAR, QUADRUPLY-STRANDED COMPOUNDS COMPRISING PALLADIUM OR PLATINUM
(FR) TRAITEMENT CONTRE LE CANCER
Abstract:
(EN) The invention relates to a compound of formula (M2L4 where: M = a palladium or platinum metal ion; L = X = -O-, -S-, -NH-, or (-CH2-)n, where n = 1, 2 or 3; R2, R4, R5, R6 are each independently selected from -H, -F, -Cl, -Br, -I, -methyl, -ethyl, -propyl, -O-methyl, -OH, -CH2OH, and - CH2CH2OH, R7, R8, R9, R10 are each independently selected from -H, -F, -Cl, -Br, -I, - methyl, -ethyl, -propyl and -O-methyl; a pharmaceutically acceptable salt, complex thereof, compositions comprising the compound or complex. The invention further relates to the use of the compound or composition in the treatment of a cancer, a microbial infection or a virus infection, to a method of treating a cancer, a microbial infection or a viral infection comprising administering to a patient a pharmaceutically acceptable amount of the compound or composition.
(FR) L'invention concerne un composé de formule 1 (M2L4) dans laquelle : M = un ion métallique palladium ou platine; L = X = -O-, -S-, -NH-, ou (-CH2-)n, où n = 1, 2 ou 3; R2, R4, R5, R6 sont chacun indépendamment choisis parmi -H, -F, -Cl, -Br, -I, -méthyle, -éthyle, -propyle, -O-méthyle, -OH, -CH2OH, et - CH2CH2OH, R7, R8, R9, R10 sont chacun indépendamment choisis parmi -H, -F, -Cl, -Br, -I, -méthyle, -éthyle, -propyle et -O-méthyle; un sel pharmaceutiquement acceptable, un complexe de celui-ci, des compositions comprenant le composé ou le complexe. L'invention concerne en outre l'utilisation du composé ou de la composition dans le traitement d'un cancer, d'une infection microbienne ou d'une infection virale, un procédé de traitement d'un cancer, d'une infection microbienne ou d'une infection virale comprenant l'administration à un patient d'une quantité pharmaceutiquement acceptable du composé ou de la composition.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)