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1. (WO2009067604) SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/067604    International Application No.:    PCT/US2008/084199
Publication Date: 28.05.2009 International Filing Date: 20.11.2008
IPC:
C07D 263/56 (2006.01), C07D 263/58 (2006.01), C07D 277/62 (2006.01), C07D 277/82 (2006.01), C07D 417/04 (2006.01), C07D 417/06 (2006.01), C07D 417/14 (2006.01), C07D 513/04 (2006.01), A61K 31/428 (2006.01), A61K 31/423 (2006.01), A61K 31/519 (2006.01), A61K 31/4439 (2006.01), A61P 29/00 (2006.01)
Applicants: DECODE GENETICS EHF [IS/IS]; Sturlugata 8, IS-101 Reykjavic (IS) (For All Designated States Except US).
SINGH, Jasbir [US/US]; (US) (For US Only).
GURNEY, Mark [US/US]; (US) (For US Only).
BURGIN, Alex [US/US]; (US) (For US Only).
SANDANAYAKA, Vincent [US/US]; (US) (For US Only).
KISELYOV, Alexander [US/US]; (US) (For US Only).
RAO, Munagala [US/US]; (US) (For US Only)
Inventors: SINGH, Jasbir; (US).
GURNEY, Mark; (US).
BURGIN, Alex; (US).
SANDANAYAKA, Vincent; (US).
KISELYOV, Alexander; (US).
RAO, Munagala; (US)
Agent: HANSEN, Philip, E.; Heslin Rothenberg Farley & Mesiti, P.C., 5 Columbia Circle, Albany, New York 12203 (US)
Priority Data:
60/989,557 21.11.2007 US
Title (EN) SUBSTITUTED BENZOAZOLE PDE4 INHIBITORS FOR TREATING INFLAMMATORY, CARDIOVASCULAR AND CNS DISORDERS
(FR) INHIBITEURS DE BENZOAZOLE PDE4 SUBSTITUÉS POUR LE TRAITEMENT DE TROUBLES INFLAMMATOIRES, CARDIOVASCULAIRES ET DU SNC
Abstract: front page image
(EN)The invention relates to substituted benzothiazoles, benzoxazoles - and their counterparts having pyridine and pyrimidine rings replacing the benzene ring - that are are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula (I) in which A and B are carbocycles or heterocycles. A particular embodiment is formula (AB).
(FR)L'invention concerne des benzothiazoles substitués, des benzoxazoles - et leurs équivalents avec des anneaux de pyridine et de pyrimidine remplaçant l'anneau benzénique - qui sont des inhibiteurs de la PDE4 utiles pour le traitement d'un accident vasculaire cérébral, d'un infarctus du myocarde et de troubles d'inflammation cardiovasculaire, ainsi que des compositions pharmaceutiques qui comprennent ces composés et des procédés pour le traitement d'un accident vasculaire cérébral, d'un infarctus du myocarde et de troubles d'inflammation cardiovasculaire chez un mammifère. Les composés ont la formule générale (I) dans laquelle A et B sont des carbocycles ou des hétérocycles. Un mode de réalisation particulier de l'invention correspond à la forme (AB).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)