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1. (WO2009066802) BIOLOGICAL MEMBRANE-INTRINSIC VIRUS-LIKE PARTICLE, AND METHOD FOR PRODUCTION THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/066802    International Application No.:    PCT/JP2008/071760
Publication Date: 28.05.2009 International Filing Date: 25.11.2008
IPC:
C12N 15/09 (2006.01), C12N 7/00 (2006.01), C12N 7/02 (2006.01)
Applicants: SCHOOL JURIDICAL PERSON KITASATO INSTITUTE [JP/JP]; 9-1, Shirokane 5-chome, Minato-ku, Tokyo 1088641 (JP) (For All Designated States Except US).
SCHOOL JURIDICAL PERSON KAKE EDUCATIONAL INSTITUTION [JP/JP]; 1-1, Ridai-cho, Okayama-shi, Okayama 7000005 (JP) (For All Designated States Except US).
KANDA, Hiromi [JP/JP]; (JP) (For US Only).
MATSUMOTO, Osamu [JP/JP]; (JP) (For US Only).
SHIBA, Tadayoshi [JP/JP]; (JP) (For US Only).
KIMURA, Taketoshi [JP/JP]; (JP) (For US Only).
TAKAMATSU, Nobuhiko [JP/JP]; (JP) (For US Only).
KIKKOU, Tatsuhiko [JP/JP]; (JP) (For US Only).
ITO, Michihiko [JP/JP]; (JP) (For US Only).
IWABUCHI, Shinichiro [JP/JP]; (JP) (For US Only)
Inventors: KANDA, Hiromi; (JP).
MATSUMOTO, Osamu; (JP).
SHIBA, Tadayoshi; (JP).
KIMURA, Taketoshi; (JP).
TAKAMATSU, Nobuhiko; (JP).
KIKKOU, Tatsuhiko; (JP).
ITO, Michihiko; (JP).
IWABUCHI, Shinichiro; (JP)
Agent: OZAWA, Nobuhiko; WIN International Patent Office, Ginza Satomura Building 5F, 27-7 Ginza 1-chome, Chuo-ku, Tokyo 1040061 (JP)
Priority Data:
2007-303832 24.11.2007 JP
Title (EN) BIOLOGICAL MEMBRANE-INTRINSIC VIRUS-LIKE PARTICLE, AND METHOD FOR PRODUCTION THEREOF
(FR) PARTICULE DE TYPE VIRUS INTRINSÈQUE À UNE MEMBRANE BIOLOGIQUE ET SON PROCÉDÉ DE FABRICATION
(JA) 生体膜内在性ウイルス様粒子及びその製造方法
Abstract: front page image
(EN)Disclosed is a method which can produce a genomic-DNA-free, pure virus-like particle reliably and at a high purity, and which can control the type, state of occurrence, configuration or the like of a molecule in a capsid readily. Also disclosed is a virus-like particle which is characterized by comprising (1) a capsid-forming protein, (2) a penton protein, and (3) at least one membrane-forming protein, all of which are proteins constituting a membrane-intrinsic virus.
(FR)L'invention porte sur un procédé qui permet de produire une particule de type virus pure, exempte d'ADN génomique, de façon fiable et à une pureté élevée, et qui permet de contrôler le type, l'état d'occurrence, la configuration ou similaire d'une molécule dans une capside de façon aisée. L'invention porte également sur une particule de type virus qui est caractérisée par le fait qu'elle comprend (1) une protéine de formation de capside, (2) une protéine du penton et (3) au moins une protéine de formation de membrane, toutes étant des protéines constituant un virus intrinsèque à une membrane.
(JA)ゲノムDNAを含まない純粋なウイルス様粒子を確実かつ高純度に製造し、かつ、キャプシド内在分子の種類や存在態様、配置等の制御を容易に行い得る方法の確立を目的とする。本発明によれば、生体膜内在性ウイルスを構成するタンパク質のうち、(1)キャプシド構成タンパク質、(2)ペントンタンパク質、及び(3)少なくとも一種の膜形成タンパク質を含むことを特徴とするウイルス様粒子が提供される。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)