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Machine translation
1. (WO2009066174) IMPROVED CYTOKINE DESIGN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/066174    International Application No.:    PCT/IB2008/003476
Publication Date: 28.05.2009 International Filing Date: 21.11.2008
IPC:
A61K 38/18 (2006.01), C07K 14/525 (2006.01)
Applicants: RIJKSUNIVERSITEIT GRONINGEN [NL/NL]; Broerstraat 5, NL-9712 CP Groningen (NL) (For All Designated States Except US).
NATIONAL UNIVERSITY OF IRELAND, GALWAY [IE/IE]; University Road, Galway (IE) (For All Designated States Except US).
TRISKEL THERAPEUTICS B.V. [NL/NL]; Antonius Deusinglaan 1, NL-9713 AV Gronigen (NL) (For All Designated States Except US).
FUNDACIO PRIVADA CENTRE DE REGULACIO GENOMICA (CRG) [ES/ES]; Doctor Aiguader 88, E-08003 Barcelona (ES) (For All Designated States Except US).
INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS (ICREA) [ES/ES]; Passeig Lluis Companys 28, E-08010 Barcelona (ES) (For All Designated States Except US).
RODRIGUES DOS REIS, Carlos, Ricardo [PT/NL]; (NL) (For US Only).
QUAX, Wilhelmus, Johannes [NL/NL]; (NL) (For US Only).
SAMALI, Afshin [IE/IE]; (IE) (For US Only).
SZEGEZDI, Eva [HU/IE]; (IE) (For US Only).
COOL, Robbert, Hans [NL/NL]; (NL) (For US Only).
VAN DER SLOOT, Albert, Martinus [NL/ES]; (ES) (For US Only).
SERRANO, Luis [ES/ES]; (ES) (For US Only).
TUR, Vicente [ES/ES]; (ES) (For US Only)
Inventors: RODRIGUES DOS REIS, Carlos, Ricardo; (NL).
QUAX, Wilhelmus, Johannes; (NL).
SAMALI, Afshin; (IE).
SZEGEZDI, Eva; (IE).
COOL, Robbert, Hans; (NL).
VAN DER SLOOT, Albert, Martinus; (ES).
SERRANO, Luis; (ES).
TUR, Vicente; (ES)
Agent: GOODFELLOW, Hugh, Robin; Carpmaels & Ransford, 43-45 Bloomsbury Square, London WC1A 2RA (GB)
Priority Data:
0723059.2 23.11.2007 GB
Title (EN) IMPROVED CYTOKINE DESIGN
(FR) CONCEPTION DE CYTOKINE AMÉLIORÉE
Abstract: front page image
(EN)The present invention relates to novel cytokines, which have a modified selectivity/specificity for their cognate receptors. In particular, the invention relates to a variant TRAIL protein, which has superior selectivity for the death receptor 4 (TRAIL-RI ) over the death receptor 5 (TRAIL-R2). In addition, the invention relates to a variant TRAIL protein which exhibits superior selectivity for the death receptor 4 (TRAIL-R1 ) over the decoy receptors DcR1 (TRAIL- R3) and DcR2 (TRAIL-R4).
(FR)La présente invention porte sur de nouvelles cytokines, qui ont une sélectivité/spécificité modifiée pour leurs récepteurs parents. En particulier, l'invention porte sur une protéine TRAIL variante, qui a une sélectivité supérieure pour le récepteur de mort 4 (TRAIL-RI) sur le récepteur de mort 5 (TRAIL-R2). De plus, l'invention porte sur une protéine TRAIL variante qui présente une sélectivité supérieure pour le récepteur de mort 4 (TRAIL-R1) sur les récepteurs de leurre DcR1 (TRAIL-R3) et DcR2 (TRAIL-R4).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)