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1. (WO2009066060) 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/066060    International Application No.:    PCT/GB2008/003871
Publication Date: 28.05.2009 International Filing Date: 18.11.2008
IPC:
C07D 249/06 (2006.01), C07D 263/32 (2006.01), C07D 263/36 (2006.01), C07D 333/16 (2006.01), C07D 213/30 (2006.01), A61K 31/05 (2006.01), A61K 31/381 (2006.01), A61K 31/4192 (2006.01), A61K 31/421 (2006.01), A61K 31/4458 (2006.01), A61K 31/4462 (2006.01), C07C 39/08 (2006.01), C07C 49/825 (2006.01), A61P 35/00 (2006.01)
Applicants: TOPOTARGET A/S [DK/DK]; Symbion 3 Fruebjergvej DK-2100 Copenhagen (DK) (For All Designated States Except US).
NORRILD, Jens, Christian [DK/DK]; (DK) (For US Only).
LAURITSEN, Anne [DK/DK]; (DK) (For US Only).
BJÖRKLING, Fredrik [SE/SE]; (SE) (For US Only).
VADLAMUDI, Sreenivasa, Murthy [GB/GB]; (GB) (For US Only)
Inventors: NORRILD, Jens, Christian; (DK).
LAURITSEN, Anne; (DK).
BJÖRKLING, Fredrik; (SE).
VADLAMUDI, Sreenivasa, Murthy; (GB)
Agent: WYTENBURG, Wilhelmus; Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS (GB)
Priority Data:
60/988,915 19.11.2007 US
0722680.6 19.11.2007 GB
61/054,953 21.05.2008 US
Title (EN) 4-SUBSTITUTED-6-ISOPROPYL-BENZENE-1,3-DIOL COMPOUNDS AND THEIR USE
(FR) COMPOSÉS 6-ISOPROPYL-BENZÈNE-1,3-DIOLS SUBSTITUÉS EN POSITION 4 ET LEUR UTILISATION
Abstract: front page image
(EN)The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 4-substituted-6-isopropyl-benzene 1,3-diol compounds (referred to herein as IBD compounds), which, inter alia, inhibit heat shock protein 90 (HSP90) function. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HSP90 function, and in the treatment of diseases and conditions that are mediated by HSP90, that are ameliorated by the inhibition of HSP90 function, etc., including proliferative conditions such as cancer, etc.
(FR)La présente invention concerne d'une manière générale le domaine des composés thérapeutiques, et elle porte plus spécifiquement sur certains composés 6-isopropyl-benzène-1,3-diols substitués en position 4 (appelés ici composés IBD), lesquels, entre autres, inhibent la fonction de la protéine de choc thermique 90 (HSP90). La présente invention porte également sur des compositions pharmaceutiques comprenant de tels composés, et sur l'utilisation de tels composés et de telles compositions, à la fois in vivo et in vitro, pour inhiber la fonction de HSP90, et dans le traitement de maladies et d'états pour lesquels le HSP90 sert d'intermédiaire, qui sont améliorés par inhibition de la fonction de HSP90, etc., comprenant des états prolifératifs tels que le cancer, etc.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)