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1. (WO2009066041) DERIVATIVES OF 1,2,4,5-TETRAHYDRO-3H-BENZAZEPINES, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/066041    International Application No.:    PCT/FR2008/001268
Publication Date: 28.05.2009 International Filing Date: 11.09.2008
IPC:
C07D 223/16 (2006.01), A61K 31/55 (2006.01), A61P 9/00 (2006.01)
Applicants: LES LABORATOIRES SERVIER [FR/FR]; 12, place de la Défense F-92415 Courbevoie Cedex (FR) (For All Designated States Except US).
PEGLION, Jean-Louis [FR/FR]; (FR) (For US Only).
GOUMENT, Bertrand [FR/FR]; (FR) (For US Only).
DESSINGES, Aimée [FR/FR]; (FR) (For US Only).
CAIGNARD, Pascal [FR/FR]; (FR) (For US Only).
VILAINE, Jean-Paul [FR/FR]; (FR) (For US Only).
THOLLON, Catherine [FR/FR]; (FR) (For US Only).
VILLENEUVE, Nicole [FR/FR]; (FR) (For US Only).
CHIMENTI, Stefano [FR/FR]; (FR) (For US Only)
Inventors: PEGLION, Jean-Louis; (FR).
GOUMENT, Bertrand; (FR).
DESSINGES, Aimée; (FR).
CAIGNARD, Pascal; (FR).
VILAINE, Jean-Paul; (FR).
THOLLON, Catherine; (FR).
VILLENEUVE, Nicole; (FR).
CHIMENTI, Stefano; (FR)
Common
Representative:
LES LABORATOIRES SERVIER [FR/FR]; 12, place de la Défense F-92415 Courbevoie Cedex (FR)
Priority Data:
0706346 11.09.2007 FR
Title (EN) DERIVATIVES OF 1,2,4,5-TETRAHYDRO-3H-BENZAZEPINES, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
(FR) DERIVES DE 1,2,4,5-TETRAHYDRO-3H-BENZAZEPINES, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
Abstract: front page image
(EN)The invention relates to compounds having formula (I), wherein R1 to R9 are as defined in claim 1, in racemic form or in the form of optical isomers, as well as the addition salts thereof with a pharmaceutically acceptable acid, which can be used in the curative or preventive treatment of all diseases in which HCN channel activity or expression is exacerbated and abnormal.
(FR)Composés de formule (I) : dans laquelle R1 à R9 ont les définitions selon la revendication 1, sous forme racémique ou d'isomères optiques, ainsi que leurs sels d'addition avec un acide pharmaceutiquement acceptable, utile dans les traitements curatifs ou préventifs de toutes les pathologies dans lesquelles l'activité ou l'expression des canaux HCN est exacerbée et anormale.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: French (FR)
Filing Language: French (FR)