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1. (WO2009065920) COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/065920    International Application No.:    PCT/EP2008/065962
Publication Date: 28.05.2009 International Filing Date: 21.11.2008
IPC:
C07D 403/14 (2006.01), C07D 471/04 (2006.01), C07D 471/10 (2006.01), C07D 471/20 (2006.01), C07D 498/10 (2006.01), A61K 31/517 (2006.01), A61K 31/527 (2006.01), A61K 31/537 (2006.01), A61P 3/10 (2006.01), A61P 9/00 (2006.01), A61P 17/00 (2006.01), A61P 19/00 (2006.01), A61P 25/06 (2006.01)
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE/DE]; Binger Strasse 173, 55216 Ingelheim am Rhein (DE) (For All Designated States Except US).
GOTTSCHLING, Dirk [DE/DE]; (DE) (For US Only).
DAHMANN, Georg [DE/DE]; (DE) (For US Only).
DOODS, Henri [NL/DE]; (DE) (For US Only).
HEIMANN, Annekatrin [DE/DE]; (DE) (For US Only).
MUELLER, Stephan Georg [DE/DE]; (DE) (For US Only).
RUDOLF, Klaus [DE/DE]; (DE) (For US Only).
SCHAENZLE, Gerhard [DE/DE]; (DE) (For US Only).
STENKAMP, Dirk [DE/DE]; (DE) (For US Only)
Inventors: GOTTSCHLING, Dirk; (DE).
DAHMANN, Georg; (DE).
DOODS, Henri; (DE).
HEIMANN, Annekatrin; (DE).
MUELLER, Stephan Georg; (DE).
RUDOLF, Klaus; (DE).
SCHAENZLE, Gerhard; (DE).
STENKAMP, Dirk; (DE)
Agent: HAMMANN, Heinz; Binger Str. 173, 55216 Ingelheim am Rhein (DE)
Priority Data:
07121350.8 22.11.2007 EP
Title (DE) VERBINDUNGEN
(EN) COMPOUNDS
(FR) NOUVEAUX COMPOSÉS
Abstract: front page image
(DE)Gegenstand der vorliegenden Erfindung sind neue CGRP-Antagonisten der allgemeinen Formel (I), in der U, V, X, Y, R1, R2, R3 und R4 wie in der Beschreibungerwähnt definiert sind, deren Tautomere, deren Isomere, deren Diastereomere, deren Enantiomere, deren Hydrate, deren Gemische und deren Salze sowie die Hydrate der Salze, insbesondere deren physiologisch verträgliche Salze mit anorganischen oder organischen Säuren oder Basen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung.
(EN)The invention relates to novel CGRP antagonists of general formula (I) in which U, V, X, Y, R1, R2, R3, and R4 are defined as indicated in the description, the tautomers, isomers, diastereomers, enantiomers, hydrates, mixtures, and salts thereof, and the hydrates of the salts, especially the physiologically acceptable salts thereof with inorganic or organic acids or bases, medicaments containing said compounds, the use thereof, and methods for the production thereof.
(FR)La présente invention concerne de nouveaux antagonistes de CGRP de formule générale (I) dans laquelle U, V, X, Y, R1, R2, R3 et R4 sont tels que définis dans la description, ainsi que les tautomères, isomères, diastéréoisomères, énantiomères, hydrates, mélanges et sels de ceux-ci, ainsi que les hydrates des sels de ceux-ci, notamment leurs sels physiologiquement compatibles avec des acides ou des bases inorganiques ou organiques, des médicaments contenant ces composés, leur utilisation et des procédés de production de ceux-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)