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1. (WO2009065897) INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/065897    International Application No.:    PCT/EP2008/065925
Publication Date: 28.05.2009 International Filing Date: 20.11.2008
IPC:
A61K 38/07 (2006.01), A61K 31/513 (2006.01), C07D 405/06 (2006.01)
Applicants: VIB VZW [BE/BE]; Rijvisschestraat 120, B-9052 Gent (BE) (For All Designated States Except US).
UNIVERSITEIT GENT [BE/BE]; Sint-Pietersnieuwstraat 25, B-9000 Gent (BE) (For All Designated States Except US).
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R & D [BE/BE]; Minderbroedersstraat 8a - bus 5105, B-3000 Leuven (BE) (For All Designated States Except US).
BEYAERT, Rudi [BE/BE]; (BE) (For US Only).
MARYNEN, Peter [BE/BE]; (BE) (For US Only).
BAENS, Thijs [BE/BE]; (BE) (For US Only).
HEYNINCK, Karen [BE/BE]; (BE) (For US Only)
Inventors: BEYAERT, Rudi; (BE).
MARYNEN, Peter; (BE).
BAENS, Thijs; (BE).
HEYNINCK, Karen; (BE)
Common
Representative:
VIB VZW; Rijvisschestraat 120, B-9052 Gent (BE)
Priority Data:
07121200.5 21.11.2007 EP
61/004,097 21.11.2007 US
Title (EN) INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF
(FR) INHIBITEURS DE L'ACTIVITÉ PROTÉOLYTIQUES DE MALT1 ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention relates to inhibitors of MALT1 proteolytic and/or autoproteolytic activity. More specifically, it relates to compounds such as, but not limited to peptide derivates such as Z-LSSR-CHO, Z-LSSR-CMK, Z-GASR-CHO, and Z-GASR-CMK, and small compounds such as 5-{[5-(3-chloro-4-methylphenyl)-2-furyl]methylene}-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione and variants thereof, and the use of those compounds for the preparation of a medicament. The invention relates further to a method to screen for inhibitors of the MALT1 proteolytic and/or autoproteolytic activity.
(FR)La présente invention concerne des inhibiteurs de l'activité protéolytique et/ou autoprotéolytique de MALT1. L'invention concerne plus spécifiquement des composés tels que, mais sans y être limités, des dérivés de peptides tels que Z-LSSR-CHO, Z-LSSR-CMK, Z-GASR-CHO et Z-GASR-CMK, des petits composés tels que la 5-{[5-(3-chloro-4-méthylphényl)-2-furyl]méthylène}-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione et ses variantes, et l'utilisation de ces composés pour la préparation d'un médicament. L'invention concerne également un procédé de criblage d'inhibiteurs de l'activité protéolytique et/ou autoprotéolytique de MALT1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)