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1. (WO2009065022) LOW DENSITY LIPOPROTEIN RECEPTOR-MEDIATED SIRNA DELIVERY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/065022    International Application No.:    PCT/US2008/083614
Publication Date: 22.05.2009 International Filing Date: 14.11.2008
IPC:
A61K 47/48 (2006.01), C12N 15/11 (2006.01), A61K 31/7088 (2006.01), A61P 27/02 (2006.01)
Applicants: ALCON RESEARCH, LTD. [US/US]; 6201 South Freeway, MS TB4-8, Fort Worth, Texas 76134-2099 (US) (For All Designated States Except US).
CHATTERTON, Jon E. [US/US]; (US) (For US Only)
Inventors: CHATTERTON, Jon E.; (US)
Agent: DERRY, Jason J.; 6201 South Freeway, MS TB4-8, Fort Worth, Texas 76134-2099 (US)
Priority Data:
60/988,162 15.11.2007 US
Title (EN) LOW DENSITY LIPOPROTEIN RECEPTOR-MEDIATED SIRNA DELIVERY
(FR) ADMINISTRATION D'ARNIC MÉDIÉE PAR UN RÉCEPTEUR DE LIPOPROTÉINE BASSE DENSITÉ
Abstract: front page image
(EN)The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a low density lipoprotein receptor (LDLR) or LDLR family member. Therapeutic uses for the conjugates are also provided.
(FR)L'invention concerne des conjugués molécule d'ARN interférent/ligand utiles en tant que système d'administration destiné à administrer des molécules d'ARN interférent à une cellule in vitro ou in vivo. Les conjugués se composent d'un ligand qui peut se lier à un récepteur de lipoprotéine basse densité (LDLR) ou à un élément de la famille des LDLR. L'invention concerne également les utilisations thérapeutiques des conjugués.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)