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Machine translation
1. (WO2009064983) METHODS AND COMPOSITIONS FOR TREATING DRY EYE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/064983    International Application No.:    PCT/US2008/083551
Publication Date: 22.05.2009 International Filing Date: 14.11.2008
IPC:
A61P 27/02 (2006.01), A61P 27/04 (2006.01), A61K 31/736 (2006.01), A61K 38/01 (2006.01), A61K 8/55 (2006.01), A61K 47/36 (2006.01)
Applicants: ALCON RESEARCH, LTD. [US/US]; 6201 South Freeway, Fort Worth, Texas 76134-2099 (US) (For All Designated States Except US).
HONG, Bor-Shyue [US/US]; (US) (For US Only).
MEADOWS, David, L. [US/US]; (US) (For US Only)
Inventors: HONG, Bor-Shyue; (US).
MEADOWS, David, L.; (US)
Agent: REIN, Michael; 6201 South Freeway, MS TB4-8, Fort Worth, Texas 76134-2099 (US)
Priority Data:
60/988,623 16.11.2007 US
Title (EN) METHODS AND COMPOSITIONS FOR TREATING DRY EYE
(FR) PROCÉDÉS ET COMPOSITIONS POUR TRAITER UN ŒIL SEC
Abstract: front page image
(EN)The present invention is directed to ophthalmic compositions containing protease-inhibiting peptide substrates. In a preferred embodiment, the protease-inhibiting peptide substrate is gelatin. The compositions may also contain a galactomannan. In a particularly preferred embodiment, the compositions contain gelatin, a galactomannan and a borate salt. The present invention also describes methods of use of these compositions to inhibit protease MMP-9, and methods of topical administration of the compositions to the eye, particularly for the treatment of dry eye.
(FR)L'invention concerne des compositions ophtalmiques contenant des substrats peptidiques inhibant une protéase. Dans un mode de réalisation préféré, le substrat peptidique inhibant une protéase est de la gélatine. Les compositions peuvent également contenir un galactomannane. Dans un mode de réalisation particulièrement préféré, les compositions contiennent de la gélatine, un galactomannane et un sel de borate. La présente invention décrit également des procédés d'utilisation de ces compositions pour inhiber la protéase MMP-9, et des procédés d'administration topique des compositions à l'œil, en particulier pour le traitement d'un œil sec.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)