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1. (WO2009064963) OXIDIZED CATIONIC POLYSACCHARIDE-BASED POLYMER TISSUE ADHESIVE FOR MEDICAL USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/064963    International Application No.:    PCT/US2008/083522
Publication Date: 22.05.2009 International Filing Date: 14.11.2008
IPC:
A61L 24/00 (2006.01), A61L 27/26 (2006.01), A61L 31/04 (2006.01), A61L 24/04 (2006.01), A61L 27/52 (2006.01), A61L 31/14 (2006.01)
Applicants: E. I. DU PONT DE NEMOURS AND COMPANY [US/US]; 1007 Market Street Wilmington, Delaware 19898 (US) (For All Designated States Except US).
LU, Helen, S., M. [US/US]; (US) (For US Only)
Inventors: LU, Helen, S., M.; (US)
Agent: LANGWORTHY, John, A.; E. I. du Pont de Nemours and Company Legal Patent Records Center 4417 Lancaster Pike Wilmington, Delaware 19805 (US)
Priority Data:
61/003,059 14.11.2007 US
Title (EN) OXIDIZED CATIONIC POLYSACCHARIDE-BASED POLYMER TISSUE ADHESIVE FOR MEDICAL USE
(FR) ADHÉSIF TISSULAIRE POLYMÈRE À BASE DE POLYSACCHARIDE CATIONIQUE OXYDÉ, À USAGE MÉDICAL
Abstract: front page image
(EN)A tissue adhesive formed by reacting an oxidized cationic polysaccharide containing aldehyde groups and amine groups with a multi-arm amine is described. The oxidized cationic polysaccharide-based polymer tissue adhesive may be useful for medical applications including wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, ophthalmic procedures, drug delivery, anti-adhesive applications and as a bulking agent to treat urinary incontinence. Additionally, due to the presence of the positively charged amine groups on the oxidized polysaccharide, the polymer tissue adhesive disclosed herein may promote wound healing and blood coagulation, and may possess antimicrobial properties.
(FR)L'invention concerne un adhésif tissulaire formé par réaction d'un polysaccharide cationique oxydé contenant des groupes aldéhyde et des groupes amine avec une amine à bras multiples. Cet adhésif tissulaire polymère à base de polysaccharide cationique oxydé trouve une utilité dans des applications médicales telles que la fermeture de plaies, l'ajout ou le remplacement de sutures ou d'agrafes dans des opérations chirurgicales internes telles que l'anastomose intestinale et l'anastomose vasculaire, les opérations ophtalmologiques, l'administration de médicaments et les applications anti-adhésives, et comme agent gonflant pour le traitement de l'incontinence urinaire. En outre, du fait de la présence des groupes amine chargés positivement sur le polysaccharide oxydé, ledit adhésif tissulaire polymère peut favoriser la cicatrisation des plaies et la coagulation du sang, et peut présenter des propriétés antimicrobiennes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)