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Machine translation
1. (WO2009064959) ISOQUINOLINE MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/064959    International Application No.:    PCT/US2008/083517
Publication Date: 22.05.2009 International Filing Date: 14.11.2008
IPC:
C07D 217/22 (2006.01), A61K 31/472 (2006.01), A61K 31/4725 (2006.01), A61P 11/00 (2006.01), C07D 401/04 (2006.01), C07D 405/12 (2006.01), C07D 405/14 (2006.01)
Applicants: VERTEX PHARMACEUTICALS INCORPORATED [--/US]; 130 Waverly Street, Cambridge, MA 02139 (US) (For All Designated States Except US).
HADIDA RUAH, Sara [US/US]; (US) (For US Only).
MILLER, Mark [US/US]; (US) (For US Only).
ZHOU, Jinglan [US/US]; (US) (For US Only).
BEAR, Brian [US/US]; (US) (For US Only).
GROOTENHUIS, Peter, D., J. [NL/US]; (US) (For US Only)
Inventors: HADIDA RUAH, Sara; (US).
MILLER, Mark; (US).
ZHOU, Jinglan; (US).
BEAR, Brian; (US).
GROOTENHUIS, Peter, D., J.; (US)
Agent: DIVERDI, Michael, J.; Vertex Pharmaceuticals Incorporated, 130 Waverly Street, Cambridge, MA 02139 (US)
Priority Data:
60/988,559 16.11.2007 US
Title (EN) ISOQUINOLINE MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
(FR) MODULATEURS D'ISOQUINOLÉINE DE TRANSPORTEURS DE CASSETTE DE LIAISON À L'ATP
Abstract: front page image
(EN)Compounds of the present invention, of formula (I) and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
(FR)L'invention concerne des composés, de la formule (I) : et des compositions pharmaceutiquement acceptables de ceux-ci, qui sont utiles en tant que modulateurs de transporteurs de cassette de liaison à l'ATP ('ABC') ou des fragments de ceux-ci, y compris un régulateur de la conductance transmembranaire de la fibrose kystique ('CFTR'). La présente invention concerne également des procédés de traitement de maladies modérées par transporteur d'ABC en utilisant des composés de la présente invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)