WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2009064747) 4(-3-(-2-(PHENYL) MORPHOLINO)-2-OXOPYRROLIDIN-1-YL)-N-(THIAZOL-2-YL) BENZENESULFON AMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF ION CHANNELS FOR THE TREATMENT OF PAIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/064747    International Application No.:    PCT/US2008/083165
Publication Date: 22.05.2009 International Filing Date: 12.11.2008
IPC:
C07D 417/14 (2006.01), A61K 31/427 (2006.01), A61P 25/04 (2006.01)
Applicants: VERTEX PHARMACEUTICALS INCORPORATED; 130 Waverly Street Cambridge, MA 02139 (US) (For All Designated States Except US).
STAMOS, Dean [US/US]; (US) (For US Only).
MARTINBOROUGH, Esther [US/US]; (US) (For US Only).
NEUBERT, Timothy [US/US]; (US) (For US Only).
NUMA, Mehdi, Michel Djamel [FR/US]; (US) (For US Only).
WHITNEY, Tara [US/US]; (US) (For US Only).
ZIMMERMANN, Nicole [DE/US]; (US) (For US Only).
KAWATKAR, Aarti, Sameer [IN/US]; (US) (For US Only)
Inventors: STAMOS, Dean; (US).
MARTINBOROUGH, Esther; (US).
NEUBERT, Timothy; (US).
NUMA, Mehdi, Michel Djamel; (US).
WHITNEY, Tara; (US).
ZIMMERMANN, Nicole; (US).
KAWATKAR, Aarti, Sameer; (US)
Agent: DIVERDI, Michael, J.; Vertex Pharmaceuticals Incorporated, 130 Waverly Street, Cambridge, MA 02139 (US)
Priority Data:
60/987,485 13.11.2007 US
61/088,141 12.08.2008 US
Title (EN) 4(-3-(-2-(PHENYL) MORPHOLINO)-2-OXOPYRROLIDIN-1-YL)-N-(THIAZOL-2-YL) BENZENESULFON AMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF ION CHANNELS FOR THE TREATMENT OF PAIN
(FR) DÉRIVÉS DE 4(-3-(-2-(PHÉNYL)MORPHOLINO)-2-OXOPYRROLIDIN-1-YL)-N-(THIAZOL-2-YL)BENZÈNESULFONAMIDE ET COMPOSÉS ASSOCIÉS, UTILISÉS COMME MODULATEURS DES CANAUX IONIQUES POUR LE TRAITEMENT DE LA DOULEUR
Abstract: front page image
(EN)The present invention relates to heterocyclic derivatives of formula I useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, like, e.g. pain., (I) or a pharmaceutically acceptable salt thereof, wherein, independently for each occurrence: ring Z is a thiazole or thiadiazole optionally substituted with 0-2 occurrences of R; V is CH2, NH, O, or S; and R, R1, R2, and R3 are hydrogen, C1-C6 aliphatic, aryl, C3-C8 cycloaliphatic, halo, CN, NO2, CF3, OCF3, OH, NH2, NH(C1-C6 aliphatic), N(C1-C6 aliphatic) 2, COOH, COO(C1 -C6 aliphatic), O(C1-C6 aliphatic), CHF2, or CH2F.
(FR)La présente invention concerne des dérivés hétérocycliques utiles comme inhibiteurs des canaux ioniques. L'invention concerne également des compositions pharmaceutiquement acceptables comprenant lesdits composés ainsi que des méthodes d'utilisation de ces compositions dans le traitement de troubles divers.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)