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1. (WO2009064425) MULTISTATE AFFINITY LIGANDS FOR THE SEPARATION AND PURIFICATION OF ANTIBODIES, ANTIBODY FRAGMENTS AND CONJUGATES OF ANTIBODIES AND ANTIBODY FRAGMENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/064425    International Application No.:    PCT/US2008/012725
Publication Date: 22.05.2009 International Filing Date: 13.11.2008
IPC:
B01D 15/08 (2006.01)
Applicants: RATIONAL AFFINITY DEVICES, L.L.C. [US/US]; EDC III, Suite 523, 211 Warren St, Newark, NJ 07103 (US) (For All Designated States Except US).
BEADLING, Leslie, C. [US/US]; (US) (For US Only).
BRAUNLIN, William, H. [US/US]; (US) (For US Only).
CUBICCIOTTI, Roger, S. [US/US]; (US) (For US Only)
Inventors: BEADLING, Leslie, C.; (US).
BRAUNLIN, William, H.; (US).
CUBICCIOTTI, Roger, S.; (US)
Agent: MCCONOUGHEY, David, M.; 179 Indiana St., Maplewood, NJ 07040 (US)
Priority Data:
61/002,827 13.11.2007 US
Title (EN) MULTISTATE AFFINITY LIGANDS FOR THE SEPARATION AND PURIFICATION OF ANTIBODIES, ANTIBODY FRAGMENTS AND CONJUGATES OF ANTIBODIES AND ANTIBODY FRAGMENTS
(FR) LIGANDS À AFFINITÉ À ÉTATS MULTIPLES POUR LA SÉPARATION ET LA PURIFICATION D'ANTICORPS, DE FRAGMENTS D'ANTICORPS ET DE CONJUGUÉS D'ANTICORPS ET DE FRAGMENTS D'ANTICORPS
Abstract: front page image
(EN)Separation of antibodies, antibody fragments, and conjugates thereof using multistate affinity ligands rationally designed and selected to undergo analytically and functionally definable conformational transitions from a first affinity state under a first operator-defined environmental condition to a second affinity state under a second operator-defined environmental condition.
(FR)L'invention concerne la séparation d'anticorps, de fragments d'anticorps et de conjugués de ceux-ci au moyen de ligands à affinité à états multiples conçus rationnellement et sélectionnés pour subir des transitions conformationnelles analytiquement et rationnellement définissables d'un premier état d'affinité dans des conditions environnementales définies par l'opérateur à un second état d'affinité sous de secondes conditions environnementales définies par l'opérateur.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)