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1. (WO2009064251) BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 066
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2009/064251    International Application No.:    PCT/SE2008/051307
Publication Date: 22.05.2009 International Filing Date: 14.11.2008
IPC:
C07C 311/51 (2006.01), A61K 31/145 (2006.01), A61P 19/00 (2006.01), C07D 209/42 (2006.01), C07D 213/04 (2006.01), C07D 213/78 (2006.01), C07D 231/14 (2006.01), C07D 263/57 (2006.01), C07D 277/56 (2006.01), C07D 277/64 (2006.01), C07D 307/68 (2006.01), C07D 307/79 (2006.01), C07D 333/38 (2006.01), C07D 405/04 (2006.01), C07D 409/06 (2006.01), C07D 417/04 (2006.01), C07D 498/04 (2006.01), C07D 333/52 (2006.01)
Applicants: ASTRAZENECA AB [SE/SE]; S-151 85 Södertälje (SE) (For All Designated States Except US).
BYLUND, Johan [SE/SE]; (SE) (For US Only).
EK, Maria [SE/SE]; (SE) (For US Only).
HOLENZ, Jörg [DE/SE]; (SE) (For US Only).
JOHANSSON, Martin H [SE/SE]; (SE) (For US Only).
KERS, Annika [SE/SE]; (SE) (For US Only).
NÄRHI, Katja [FI/SE]; (SE) (For US Only).
NORDVALL, Gunnar [SE/SE]; (SE) (For US Only).
ÖHBERG, Liselotte [SE/SE]; (SE) (For US Only).
SOHN, Daniel [US/SE]; (SE) (For US Only).
VIKLUND, Jenny [SE/SE]; (SE) (For US Only).
VON BERG, Stefan [DE/SE]; (SE) (For US Only)
Inventors: BYLUND, Johan; (SE).
EK, Maria; (SE).
HOLENZ, Jörg; (SE).
JOHANSSON, Martin H; (SE).
KERS, Annika; (SE).
NÄRHI, Katja; (SE).
NORDVALL, Gunnar; (SE).
ÖHBERG, Liselotte; (SE).
SOHN, Daniel; (SE).
VIKLUND, Jenny; (SE).
VON BERG, Stefan; (SE)
Agent: ASTRAZENECA AB; AstraZeneca Intellectual Property, S-151 85 Södertälje (SE)
Priority Data:
60/988,164 15.11.2007 US
Title (EN) BIS-(SULFONYLAMINO) DERIVATIVES IN THERAPY 066
(FR) DÉRIVÉS BIS-(SULFONYLAMINO) DANS UNE THÉRAPIE 066
Abstract: front page image
(EN)The invention provides compounds of formula wherein R1, R3, L1, L2, G1, G2, A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of microsomal prostaglandin E synthase-1.
(FR)La présente invention concerne des composés représentés par la formule I. Dans cette formule, R1, R3, L1, L2, G1, G2, A et m sont tels que définis dans la spécification, et des isomères optiques, des racémates et des tautomères de ceux-ci ainsi que des sels pharmaceutiquement acceptables de ceux-ci, avec des processus pour leur préparation, des compositions pharmaceutiques contenant ces composés et leur utilisation en thérapie. Ces composés sont des inhibiteurs de prostaglandine E synthase -1 microsomale.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)